DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and Est-Q

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	157/551 - (28%)
Similarity:	266/551 - (48%)	Gaps:	90/551 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ASSSVLSIEV----DTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKI 74
            :.::.:::|:    .|.||.......|.|.   |..||||.:||||:.:|||..|....||:..:
  Fly    37 SETATVTVELYNGQGTVLGNYAYTAWTDRA---FMQFRGIPFAEPPIEELRFRPPVARSPWTGTL 98

  Fly    75 FDASEDGPMCPQPWD---NMTDVS-EDCLRLNVYTKDLKGRRPVIVFLHPGGFYVFSGQSKYLAG 135
             :|...|..||...:   .|:|.. ||||.|:||||:|...:||:.:::.||||..|.:..   .
  Fly    99 -NALNFGQRCPVITNLDSQMSDAELEDCLTLSVYTKNLSASQPVMFYIYGGGFYNGSSEDH---P 159

  Fly   136 PEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLG 200
            |.:.:::|.|||...||:|:||:|:|.::|.||||.:.|.::||.|:|.||..|||||..||:.|
  Fly   160 PNYLLEKDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFG 224

  Fly   201 YSAGSISVALHMLSPMS-RGLFHRGICMSAAPYGPVKYKDNDLQLAKR---QAGLLKCPQESIGE 261
            .|||:...:..:|||.: ..:|.|.|..|.:.:.......:....::|   |.|...|.|..  :
  Fly   225 QSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQHD--Q 287

  Fly   262 MVECMRRKPYLDYV-STYNGMFEFGWNPVLNWRIVVEKDFGQERYLIESP---FKTARRGDFHKV 322
            :|:|:::...:|.: :|.:..|    :|::.         .....|.:.|   .|:.||    ::
  Fly   288 LVKCIQKAKVIDILKATASESF----SPIVG---------DLHGILPQQPSELVKSYRR----QI 335

  Fly   323 ALITGITEFE--FLSGAFFDLRNESIVNRYNRDWEHYA-SIALLLEQNSTQSRAASRVFREKYMP 384
            .::||.|:.:  |:..:::|.....:.|..:.....:: .|..|:  |.|.....:.:.|..:.|
  Fly   336 PILTGFTQHDGSFVLASYYDALAAKVANVSSLSVRQFSQGINDLV--NDTSGLTDNILNRLLFKP 398

  Fly   385 ESLDKLEYPKSLKGMGEL-----LSDALIGVSFHRFLQLMSPHTPIYTYLFRYKGRYTFL----- 439
            ::|:..::..::....:|     :...:|.::...:.|..|  ||:|.|.|.|:|.||..
  Fly   399 QALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRS--TPVYVYSFEYEGTYTRFGYEFG 461

  Fly   440 --KNPDNQQTIGPVHH-DELIYLF--HVGLLIPLLKREDPENFMIELLTRMWIEFAQKGDPHNKN 499
              ..|.|    |.||| ::.||||  |     ||   |..:..|.:.:..:|..||.:|.|.|.:
  Fly   462 NSHYPFN----GGVHHSNDNIYLFATH-----PL---EGQDTQMSQKMVDVWTSFAIEGVPRNLS 514

  Fly   500 DEYLKGLNWPLYNAQ---DKGYLEI--GNNL 525
                     ||.:|.   :|..||:  |::|
  Fly   515 ---------PLSSASGPYNKLNLEVTKGDDL 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	157/550 (29%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	71/167 (43%)
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	157/549 (29%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	44/105 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.870