Protein Alignment CG4757 and Ces3a

DIOPT Version :9

• Sequence 1: NP_001262469.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_941074.1
• Gene: Ces3a / 382053
• MGIID: 102773
• Length: 571
• Species: Mus musculus
• Alignment Length: 597
• Identity: 189/597 - (31%)
• Similarity: 274/597 - (45%)
• Gaps: 105/597 - (17%)

  Fly     1 MLMLFVVELLVLLASSSVLSIEVDTELGRVRGANL----TSRLGVNFHAFRGIRYAEPPLGDLRF 61
            :|::|...::    ...|...||||.||||||..:    |.|: ||  .|.||.:|:.|||.|||
Mouse    21 LLLIFPTTVI----GPKVTQPEVDTPLGRVRGRQVGVKDTDRM-VN--VFLGIPFAQAPLGPLRF 78

  Fly    62 VNPQPVKPWSPKIFDASEDGPMCPQPWDNMTD-------------VSEDCLRLNVY--TKDLKG- 110
            ..|.|.:||. .:.|||.:.|||.|..:.|::             :|||||.||:|  |:...|
Mouse    79 SAPLPPQPWE-GVRDASINPPMCLQDVERMSNSRFTLNEKMKIFPISEDCLTLNIYSPTEITAGD 142

  Fly   111 RRPVIVFLHPGGFYVFSGQSKYLAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQ 175
            :|||:|::|.|...|  |.|....|.......|.|:|::.||||..|||:||.|..|||.|..|.
Mouse   143 KRPVMVWIHGGSLLV--GSSTSHDGSALAAYGDVVVVTVQYRLGIFGFLSTGDKHMPGNRGFLDV 205

  Fly   176 VLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDN 240
            |.||||:|.:|..|||||:.||:.|.|||.|.|:..:|||||.|||||.|..|......:....|
Mouse   206 VAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVISKILEDLN 270

  Fly   241 DLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIVVEKDFGQERY 305
            ....|:..|..:.|...|..|:|:|:.:|...|.::..|          :|....|...|..:|
Mouse   271 AWSEAQNFANSVACGSASPAELVQCLLQKEGKDLITKKN----------VNISYTVNDSFFPQR- 324

  Fly   306 LIESPFKTARRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYASIALLLEQNSTQ 370
                |.|......|..|..:.|:|..||   .:..|:..:|:::    .||.:...||  :||..
Mouse   325 ----PQKLLANKQFPTVPYLLGVTNHEF---GWLLLKFWNILDK----MEHLSQEDLL--ENSRP 376

  Fly   371 SRAASRVFREKYMPESLDKLEY-------PKSLKGMGELLSDALIGVS---FHRFLQLMSPHTPI 425
            ..|..::..| .||..:|  ||       ..:...:.|||.|..:.:.   |.::||  ....|:
Mouse   377 LLAHMQLPPE-IMPTVID--EYLDNGSDESATRYALQELLGDITLVIPTLIFSKYLQ--DAGCPV 436

  Fly   426 YTYLFRY------KGRYTFLKNPDNQQTI----GPVHHDELIYLFHVGLLIPLLKREDPENFMIE 480
            :.|.|::      |.:..::|...:.:..    ||...||       ..|:...:..:.|..:..
Mouse   437 FLYEFQHTPSSFAKFKPAWVKADHSSENAFVFGGPFLTDE-------SSLLAFPEATEEEKQLSL 494

  Fly   481 LLTRMWIEFAQKGDPHNKNDEYLKGL-NWPLYNAQDKGYLEIG----NNLTAKSGGFFLNRYQIW 540
            .:...|.:||:.|:|:.      ||| .||..| |.:.|||||    ..:..|.|     |.|.|
Mouse   495 TMMAQWSQFARTGNPNG------KGLPPWPQLN-QLEQYLEIGLEPRTGVKLKKG-----RLQFW 547

  Fly   541 EDLFP--LSSFH 550
            .:..|  :..:|
Mouse   548 TETLPRKIQEWH 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	184/569 (32%)
		Aes	40..>204	CDD:223730	78/179 (44%)
Ces3a	NP_941074.1	COesterase	36..547	CDD:278561	183/564 (32%)
		Aes	75..>245	CDD:223730	74/172 (43%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832498
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3450
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.890