DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and Ces1b

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001074841.1	Gene:	Ces1b / 382044	MGIID:	3779470	Length:	567	Species:	Mus musculus

Alignment Length:	597	Identity:	183/597 - (30%)
Similarity:	269/597 - (45%)	Gaps:	148/597 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VDTELGRVRGANLTSRLGVNFH---AFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMC 84
            |||..|::.| ..||..|.. |   .|.|:.:|:||||.|||..|:|.:||| .:.:|:...|||
Mouse    26 VDTTQGKILG-KYTSLEGFE-HPVAVFLGVPFAKPPLGSLRFAPPEPAEPWS-FVKNATSYPPMC 87

  Fly    85 PQ---PWDNMTDV------------SEDCLRLNVYT-KDL--KGRRPVIVFLHPGGFYVFSGQSK 131
            .|   ....::|:            |||||.||:|: .||  ....||:|::|.||. :..|.|.
Mouse    88 SQDAVAVQLLSDMLSTKKESIPPLFSEDCLYLNIYSPADLTKSSLLPVMVWIHGGGL-MTGGASL 151

  Fly   132 Y--LAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPD 194
            |  ||...|   .:.|:|::.||||..|..:||.:.:.||....||:.||||:|.:|..|||:||
Mouse   152 YNGLALSAH---ENVVVVTIQYRLGIWGLFSTGDEHSRGNWAHLDQLAALRWVQDNIANFGGNPD 213

  Fly   195 SVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDN-----DL---QLAKRQAGL 251
            |||:.|.|||.:||::.:|||:::.||||.|..|:.      ..:|     ||   .|::..|.:
Mouse   214 SVTVFGSSAGGVSVSVLVLSPLAKNLFHRAISESSV------VLENIVITLDLVACDLSQMIATV 272

  Fly   252 LKCPQESIGEMVECMRRKPYLDYVSTYNGMFEF--------------------GWNPVLNWRIVV 296
            ..|...|...||:|:|:|       |.|.:.|.                    ..:.|:: .:|:
Mouse   273 SGCNDTSSTAMVQCLRQK-------TENELLEITVKLEVTKVGGAASAKKDNTSMSTVID-GVVL 329

  Fly   297 EKDFGQERYLIESPFKTARRGDFHKVALITGITEFEF---LSGAFFDLRNESIVNRYNRDWEHYA 358
            .|  ..|..|.|..|.|        |..|.|..:.||   :.....||.:|..:|      |..|
Mouse   330 PK--APEEILAEKSFST--------VPYIVGFNKQEFGWIIPTMLGDLLSEGKMN------EETA 378

  Fly   359 SIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKG----------MGELLSDALIG---V 410
            |:.|            .|...:..:.|||......|.|:|          :.::.||...|   |
Mouse   379 SLLL------------RRFHSDLNISESLIPAVIEKYLRGTDDPAKKRDLLLDMFSDVFFGIPAV 431

  Fly   411 SFHRFLQLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKR--ED 473
            ...|.|:.....|  |.|.|||:..:...|.|   ||:...|.||:..:|.    |||||.  .:
Mouse   432 LLSRSLRDAGVST--YMYEFRYRPSFVSDKRP---QTVEGDHGDEIFSVFG----IPLLKEGTSE 487

  Fly   474 PENFMIELLTRMWIEFAQKGDPHNKNDEYLKGL-NWPLYNAQDKGYLEIG------NNLTAKSGG 531
            .|..:.:::.:.|..||:.|:|:.      :|| :||.|: :.:|||:||      ..|.|:...
Mouse   488 EETNLSKMVMKFWANFARNGNPNG------EGLPHWPEYD-EKEGYLQIGATTQQAQRLKAEEVA 545

  Fly   532 FFLNRYQIWEDL 543
            |       |.:|
Mouse   546 F-------WTEL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	181/592 (31%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	74/186 (40%)
Ces1b	NP_001074841.1	COesterase	19..547	CDD:278561	181/592 (31%)
Ces1b	NP_001074841.1	Aes	<121..>239	CDD:223730	51/121 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832595
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3450
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.900