Protein Alignment CG4757 and AADACL2

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_997248.2
• Gene: AADACL2 / 344752
• HGNCID: 24427
• Length: 401
• Species: Homo sapiens
• Alignment Length: 293
• Identity: 61/293 - (20%)
• Similarity: 122/293 - (41%)
• Gaps: 67/293 - (22%)

  Fly    43 FHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMCPQPWDNMTDVSEDCLRLNVYTKD 107
            |...|.:||.|       |::         .||......|:..: :..:||.:...:.:.:|...
Human    50 FENMRIMRYEE-------FIS---------MIFRLDYTQPLSDE-YITVTDTTFVDIPVRLYLPK 97

  Fly   108 LKG--RRPVIVFLHPGGFYVFSGQSKYLAGPEHFMDR------DCVLVSLNYRLGSLGFLATGSK 164
            .|.  ||..:::.|.|||..  |.||..|  ..|::|      |.|:|.::|||
Human    98 RKSETRRRAVIYFHGGGFCF--GSSKQRA--FDFLNRWTANTLDAVVVGVDYRL----------- 147

  Fly   165 EAPGN---AGLKDQVLALRW--IQQHIQRFGGDPDSVTLLG-YSAGSISVALHMLSPMSRGLFHR 223
             ||.:   |..:|.:.|:::  :::.:.::|.||..:.:.| .|.|:::.|:.........:.|:
Human   148 -APQHHFPAQFEDGLAAVKFFLLEKILTKYGVDPTRICIAGDSSGGNLATAVTQQVQNDAEIKHK 211

  Fly   224 GICMSAAPYGPVKYKDNDLQLAKRQAGLLKCPQESIGEMVE-----------CMRRKPYLDYVST 277
             |.|....|..::..|:.|...:.....:...::...::|.           .|||..::...|.
Human   212 -IKMQVLLYPGLQITDSYLPSHRENEHGIVLTRDVAIKLVSLYFTKDEALPWAMRRNQHMPLESR 275

  Fly   278 YNGMFEFGWNPVLNWRIVVEKDFGQERYLIESP 310
            :  :|:|     :||.|::.:.:.:: |:...|
Human   276 H--LFKF-----VNWSILLPEKYRKD-YVYTEP 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	61/293 (21%)
AADACL2	NP_997248.2	Abhydrolase_3	107..372	CDD:400284	46/219 (21%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	111..113		1/1 (100%)