Protein Alignment CG4757 and AADACL4

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001013652.1
• Gene: AADACL4 / 343066
• HGNCID: 32038
• Length: 407
• Species: Homo sapiens
• Alignment Length: 428
• Identity: 89/428 - (20%)
• Similarity: 146/428 - (34%)
• Gaps: 140/428 - (32%)

  Fly    34 NLTSRLGV----NFHAF--RGIRYAEPP---LGDLRFVNPQPVKPWSPKIFDASEDGPMCPQPWD 89
            |:..:||:    .|..|  ..:|..:.|   :.|||| ...||:.:.||   |:...|
Human    58 NIFEKLGICSMPKFIRFLHDSVRIKKDPELVVTDLRF-GTIPVRLFQPK---AASSRP------- 111

  Fly    90 NMTDVSEDCLRLNVYTKDLKGRRPVIVFLHPGGFYVFS------GQSKYLAGPEHFMDRDCVLVS 148
                                  |..|:|.| ||..||.      |...|||     .:.:.||:.
Human   112 ----------------------RRGIIFYH-GGATVFGSLDCYHGLCNYLA-----RETESVLLM 148

  Fly   149 LNYRLGSLGFLATGSKEAPGN---AGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVAL 210
            :.||            :.|.:   |..:|.:.|.....:.::.:|.||..|.:.|.|.|..:||.
Human   149 IGYR------------KLPDHHSPALFQDCMNASIHFLKALETYGVDPSRVVVCGESVGGAAVAA 201

  Fly   211 HMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYV 275
            ...:.:.|....| |......|..|            ||..|:.|.....:.|..:.||..:..:
Human   202 ITQALVGRSDLPR-IRAQVLIYPVV------------QAFCLQLPSFQQNQNVPLLSRKFMVTSL 253

  Fly   276 STYNGMFEFGW-NPVLN--------WRIV--------VEKDFGQERYLIESPFKTARRGDFHKVA 323
            ..|..: :..| :.:||        ||..        :.|.|....|...||      |.|::.|
Human   254 CNYLAI-DLSWRDAILNGTCVPPDVWRKYEKWLSPDNIPKKFKNRGYQPWSP------GPFNEAA 311

  Fly   324 LITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYASI--ALLLEQNSTQSRAASRVFREKYMPES 386
            .:.        :....|:.|..::    .|.|..|.:  |.|:...:...|..|.:::::...:.
Human   312 YLE--------AKHMLDVENSPLI----ADDEVIAQLPEAFLVSCENDILRDDSLLYKKRLEDQG 364

  Fly   387 L------------------DK--LEYPKSLKGMGELLS 404
            :                  ||  |.:|.|||.:..::|
Human   365 VRVTWYHLYDGFHGSIIFFDKKALSFPCSLKIVNAVVS 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	89/428 (21%)
AADACL4	NP_001013652.1	alpha/beta hydrolases	115..378	CDD:473884	63/312 (20%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	119..121		1/2 (50%)