DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and CG4382

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	250/547 - (45%)
Similarity:	360/547 - (65%)	Gaps:	21/547 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LASSSVLS-IEVDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFD 76
            :.|:..|| :.:.|.||::||..|.|:.|.||:|||||.||:||:..|||..|:||:.|...: |
  Fly    35 IGSNKELSDLVITTALGKIRGTILPSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTL-D 98

  Fly    77 ASEDGPMCPQPWDNMTDVSEDCLRLNVYTKDLKG------RRPVIVFLHPGGFYVFSGQSKYLAG 135
            |:.|||.|||......||||||||:|:|||:|..      |||||||:||||||..|||||..||
  Fly    99 ATFDGPKCPQLGLVSGDVSEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQSKNFAG 163

  Fly   136 PEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLG 200
            |::||:|..|||:.|||||||||||||::|||||.||||||..|||::.||.||||||.|:||||
  Fly   164 PQYFMNRRLVLVTFNYRLGSLGFLATGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLG 228

  Fly   201 YSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAKRQAGLLKCPQESIGEMVEC 265
            |.||:::|.|||:|||||||||:.|.||.|..|.....|:.:.:|.:||.||.|..|::.||::|
  Fly   229 YGAGAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQWSLPDHQMDVATKQATLLHCHTENVTEMMDC 293

  Fly   266 MRRKPYLDYVSTYNGMFEFGW-NPVLNWRIVVEKDFGQERYLIESPFKTARRGDFHKVALITGIT 329
            ::.|.||::.:|...||||.. ||::.|:.|:|.||||||:|:|.|.::.:..||.||.:|||:|
  Fly   294 LKGKHYLEFANTLPKMFEFDRNNPLILWKPVIEPDFGQERFLVEEPIRSYQNDDFMKVPIITGMT 358

  Fly   330 EFEFLSGAFFDLRNESIVNRYNRDWEHYASIALLLEQNSTQSRAA--SRVFREKYMPESLDKLEY 392
            :.||:..|...|::.::::..|.::|..|.:..:  .|::.:||.  |:..|..|.|:.|  ::.
  Fly   359 KDEFVGPALSILQSPTLLSALNENFESLAPVFFM--YNTSDARACNISQELRNHYFPDKL--IDA 419

  Fly   393 PKSLKGMGELLSDALIGVSFHRFLQLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELI 457
            .:||:.:..|.||||.|...|||:.|.:..|.:|.|.|.|:|..:.:..|:: ...|.||||:|:
  Fly   420 NRSLEALSNLYSDALTGFGIHRFVHLAARSTKVYYYRFSYQGARSHIYYPED-APYGVVHHDDLM 483

  Fly   458 YLFHVGLLIPLLKREDPENFMIELLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLEIG 522
            |||....:..:...:|.|..|::::.||:..||.||||:...|..|:.:.|..::.:.:.||:||
  Fly   484 YLFVEPSISRMFTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDLALRDIRWRPFSFKKRYYLDIG 548

  Fly   523 NNLTAKSGGFFLN--RYQIWEDLFPLS 547
            .::|.:..   ||  .|:||:.||||:
  Fly   549 KHITLEEN---LNAENYEIWKRLFPLN 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	244/536 (46%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	108/169 (64%)
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	243/532 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467331
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3697
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102505at50557
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	10	9.900