DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and Ces5a

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001012056.2	Gene:	Ces5a / 307660	RGDID:	1549717	Length:	575	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	172/575 - (29%)
Similarity:	258/575 - (44%)	Gaps:	117/575 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 TELGRVRG--ANLTSRL-GVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMCPQ 86
            |.||.|:|  |.:..|| .||  .|.||.:|.||||.|||.||||..||. .:.:|:....:|.|
  Rat    35 TRLGWVQGKQATVLGRLEPVN--VFLGIPFAAPPLGPLRFSNPQPPIPWH-DLREATTYPNVCFQ 96

  Fly    87 --PW----DNM-------TDVSEDCLRLNVYTKDLK---GRRPVIVFLHPGGF-----YVFSGQS 130
              .|    .|:       ..||||||.||:|.....   .|.||::::..|||     .:|.|.:
  Rat    97 NLEWLFIYQNLLKVHYPKLGVSEDCLYLNIYAPAYANDGSRLPVMMWIPGGGFETGSASIFDGSA 161

  Fly   131 KYLAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDS 195
              ||..|     |.::|::.||||..||..|.::.||||...:||:.||:|::::|..|||:|||
  Rat   162 --LAAYE-----DVLIVTIQYRLGIFGFFNTQNQHAPGNWAFQDQLAALQWVRENINYFGGNPDS 219

  Fly   196 VTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGP-VKYKDNDLQLAKR-QAGLLKCPQES 258
            ||:.|.|||:||::..:|||:|.|||||.|..|.....| :|..|::|:...: .|.:.||....
  Rat   220 VTIFGGSAGAISISSLILSPLSAGLFHRAIMQSGVAIIPSLKNFDDELKHGLQVVADVCKCNVSD 284

  Fly   259 IGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIVVEKDFGQERYLIESPFKTARRGDFHKVA 323
            ...:::|:|.|..|:.:|       .|.......|:|....|.:|      |.:...:..|..|.
  Rat   285 SKVLLKCLREKSSLELLS-------LGQKTKAFTRVVDGSFFPEE------PMELLSQKTFKTVP 336

  Fly   324 LITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPE--- 385
            .|.|:...|  .|....:|.                 |..:...|.:|.|.:.:....::|.
  Rat   337 SIIGVNNQE--CGYILPMRE-----------------APEILFGSNESTALTLIHVLLHIPPQYM 382

  Fly   386 ---SLDKLEYPKSLKGMGELLSDALIGVSF----------HRFLQLMSPHTPIYTYLFRYKGRYT 437
               :.|......||..:.:.|.|....|.|          ||     ....|:|.|.|:::
  Rat   383 HIVAKDYFHGKHSLTDIRDTLLDLFGDVFFVVPGLVTARNHR-----DAGGPVYFYEFQHR---- 438

  Fly   438 FLKNPDNQQTIGPV-----HHDELIYLFH----VGLLIPLLKREDPENFMIELLTRMWIEFAQKG 493
                |:..|...|.     |.||:.::|.    .|.::...:..:.|..:...:...|..||:.|
  Rat   439 ----PNCFQNTRPAFVKADHTDEIRFVFGGPFLEGDVVMFEEATEDEKLLSRKMMSYWANFARSG 499

  Fly   494 DPHNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSGGFFL--NRYQIWEDLFPL 546
            || |.:|..|    ||.|: |::.||::..|:   |.|:.|  .|.:.|.|..||
  Rat   500 DP-NGDDLPL----WPAYD-QNESYLKLDVNI---STGWRLKDRRVEFWTDTLPL 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	168/567 (30%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	73/184 (40%)
Ces5a	NP_001012056.2	Esterase_lipase	40..529	CDD:238191	162/552 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336107
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.890