Protein Alignment CG4757 and Ces1e

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_113753.2
• Gene: Ces1e / 29225
• RGDID: 621508
• Length: 561
• Species: Rattus norvegicus
• Alignment Length: 608
• Identity: 179/608 - (29%)
• Similarity: 273/608 - (44%)
• Gaps: 125/608 - (20%)

  Fly     9 LLVLLAS------SSVLSIEVDTELGRVRG-----ANLTSRLGVNFHAFRGIRYAEPPLGDLRFV 62
            :||.||:      .|.|.: |||..|:|.|     ...|..:.|    |.|:.:|:||||.|||.
  Rat     7 ILVFLAAFTAGGHPSSLPV-VDTLQGKVLGKYVSLEGFTQPVAV----FLGVPFAKPPLGSLRFA 66

  Fly    63 NPQPVKPWSPKIFDASEDGPMCPQP--------------WDNMT-DVSEDCLRLNVYT-KDL--K 109
            .|||.:||| .:.:.:...|||.|.              .:|:: ..|||||.||:|| .||  :
  Rat    67 PPQPAEPWS-FVKNTTSYPPMCSQDPVAGQIVNDLLTNREENISLQFSEDCLYLNIYTPADLTKR 130

  Fly   110 GRRPVIVFLHPGGFYVFSGQSKY--LAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGL 172
            .|.||:|::|.||. |..|.|.|  ||...|   .:.|:|.:.||||..||.:||.:.:.||.|.
  Rat   131 DRLPVMVWIHGGGL-VLGGASTYDGLALSTH---ENVVVVVIQYRLGIWGFFSTGDEHSRGNWGH 191

  Fly   173 KDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKY 237
            .|||.||.|:|.:|..|||||.|||:.|.|||..||::.:|||:::.|||:.|..|.........
  Rat   192 LDQVAALHWVQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFHKAISESGVALTAGLV 256

  Fly   238 KDNDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYVSTY------------NGMFEFGWNPVL 290
            |.|...||::.|.:..|...:...||.|:|:|...:.:.|.            :....:.:.|.:
  Rat   257 KKNTRPLAEKIAVVSGCKSTTSAAMVHCLRQKTEEELLETTLKLNLFSLDLHGDSRQSYPFVPTV 321

  Fly   291 NWRIVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFEF-------LSGAFFDLRNESIVN 348
            ...:|:.|          .|.:.....||:.|..|.||.:.||       ::....|::.:.:
  Rat   322 LDGVVLPK----------MPEEILAEKDFNTVPYIVGINKQEFGWILPTMMNYPPSDMKLDPM-- 374

  Fly   349 RYNRDWEHYASIALLLEQNS---TQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGV 410
                      :...||:::|   .....|..|..|||:..:.|.   .::...:.||:.|.:.||
  Rat   375 ----------TATSLLKKSSFLLNLPEEAIPVAVEKYLRHTDDP---DRNKDQLLELIGDVIFGV 426

  Fly   411 SF------HRFLQLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLL 469
            ..      ||     ......|.|.|:|:..::....|   .|:...|.||:..:|...:|....
  Rat   427 PSVIVSRGHR-----DAGARTYMYEFQYRPSFSSKMKP---STVVGDHGDEIYSVFGAPILRGGT 483

  Fly   470 KREDPENFMIELLTRMWIEFAQKGDPHNKNDEYLKGL-NWPLYNAQDKGYLEIG------NNLTA 527
            .:|  |..:.:::.:.|..||:.|:|:.      :|| :||.|: |.:|||:||      ..|..
  Rat   484 SKE--EINLSKMMMKFWANFARNGNPNG------QGLPHWPEYD-QKEGYLQIGATTQQAQKLKE 539

  Fly   528 KSGGFFLNRYQIWEDLFPLSSFH 550
            |...|       |.:|..:...|
  Rat   540 KEVAF-------WSELLAMKPLH 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	170/579 (29%)
Ces1e	NP_113753.2	COesterase	24..545	CDD:395084	170/579 (29%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561