DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and Ces2i

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	XP_008758816.2	Gene:	Ces2i / 292152	RGDID:	1565045	Length:	558	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	172/588 - (29%)
Similarity:	269/588 - (45%)	Gaps:	101/588 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LFVVE--LLVLL----ASSSVLSIEVDTELGRVRGANL---TSRLGVNFHAFRGIRYAEPPLGDL 59
            |:||.  ||:||    ...|...|. :|:.|:|||:.:   .::.||  |.|.||.:|:||:|.|
  Rat    10 LYVVACGLLLLLQHVHGQDSASPIR-NTQTGQVRGSFVHVKDTKSGV--HTFLGIPFAKPPVGPL 71

  Fly    60 RFVNPQPVKPWSPKIFDASEDGPMCPQPWDNM--------------TDVSEDCLRLNVYT----- 105
            .|..|:..:||| .:.|.:....||.|. |.|              |.:|||||.||:||
  Rat    72 HFAPPEDPEPWS-GVRDGTSQPDMCLQT-DIMKEDFIKEMKLTMHPTPMSEDCLYLNIYTPAHAR 134

  Fly   106 --KDLKGRRPVIVFLHPGGFYVFSGQ---SKYLAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKE 165
              .:|    ||:|::|.||..:.|..   :..||..|     :.|:|::.||||.|||.:||.:.
  Rat   135 EGSNL----PVMVWIHGGGLVLGSASMNVASTLAATE-----EIVIVAIQYRLGILGFFSTGDEH 190

  Fly   166 APGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAA 230
            |.||.|..|||.||.|:||:|..|||:...||:.|.|||..||:.|::||||:||||..|..|..
  Rat   191 ARGNWGYLDQVAALCWVQQNIAYFGGNHGKVTIFGVSAGGTSVSSHVVSPMSKGLFHGAIMQSGV 255

  Fly   231 PYGPVKYKDNDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYVSTYNGMFEF--GWNPVLNWR 293
            ...|....|....:.|..|.|..|.......::.|:|.|...: :...|.:|:.  |
  Rat   256 ALLPDLISDTSEVVYKTVANLSGCEASDSEALIRCLRAKSKQE-ILAINQVFKMIPG-------- 311

  Fly   294 IVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYA 358
             ||:     .::|.:.|.:....||||.|..|.|:...|...|....:..:.|:.:..||
  Rat   312 -VVD-----GKFLPKHPQELLASGDFHPVPSIIGVNTDECGLGVPMFMGLDHIIKKITRD----- 365

  Fly   359 SIALLLEQNSTQSRAASR---VFREKYMPESLDKLEYPKSL-KGMGELLSDALIGVSFHRFLQLM 419
            ::..:|:..:.|......   :..|:||.::.|    |::| :...|:|.|.:..:.........
  Rat   366 TLPTVLKSTAAQMMLPPECIDLIMEEYMGDTED----PETLQEQFKEMLGDFMFVIPALEVAHFQ 426

  Fly   420 SPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHV---GLLIPLLKREDPENFMIEL 481
            ....|:|.|.|::...:.....|.:   :...|.|:::::|..   |:...:.:.|       ||
  Rat   427 RSQAPVYFYEFQHLPSFIKQVRPSH---VKADHGDDILFVFSSYFWGMNFDITEEE-------EL 481

  Fly   482 LTR----MWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQIWED 542
            |.|    .|..||:.|:|::::..|     ||:.:..:: ||:: |...|........|.|.|..
  Rat   482 LKRRVMKYWANFARNGNPNSEDLPY-----WPVLDHNEQ-YLQL-NTQPAVGRALKARRLQFWTK 539

  Fly   543 LFP 545
            ..|
  Rat   540 TLP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	163/564 (29%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	74/187 (40%)
Ces2i	XP_008758816.2	COesterase	30..537	CDD:395084	162/561 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336229
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.990