DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and Ces4a

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001099646.1	Gene:	Ces4a / 291955	RGDID:	1307418	Length:	563	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	169/578 - (29%)
Similarity:	261/578 - (45%)	Gaps:	98/578 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SSVLSIEVDTELGRVRGAN--LTSRLGV-----------NFHAFRGIRYAEPPLGDLRFVNPQPV 67
            |..|.:.|.|.||.:....  |.::.|:           ....|.|:.:::||:|..||..|:|.
  Rat    15 SLTLWLVVQTALGALHTKEPLLITKHGILQGKQVHVGDTPIRVFLGVPFSQPPVGTRRFAPPEPP 79

  Fly    68 KPWSPKIFDASEDGPMCPQ-PWDNMTDV-------------SEDCLRLNVYTKDLKGRRPV--IV 116
            .||: .|.||:...|.|.| .|..:|.:             |||||.||||...|....|:  ::
  Rat    80 LPWN-GIRDATTYPPSCLQESWGQITSMYLNTRKQYEWLHFSEDCLYLNVYAPVLAPGDPLLPVM 143

  Fly   117 FLHPGGFYVFSGQSKYLAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRW 181
            ...|||.::....|.| .|.|.......|||.|.||||.|||.:||:..|.||.||.||:.||||
  Rat   144 VWFPGGAFLVGSASTY-EGSELAARGKVVLVFLQYRLGILGFFSTGNSHARGNWGLLDQIAALRW 207

  Fly   182 IQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAK 246
            :|::|:.||||||||||.|.|||::||:..::||:::||||:.|..|...........:.|:.||
  Rat   208 VQENIEAFGGDPDSVTLFGQSAGAMSVSGLLMSPLAQGLFHQAISQSGTAVLKTFITHDPLKSAK 272

  Fly   247 RQAGLLKCPQESIGEMVECMRRKPYLDYVSTYNGMFEFGWN-------------PVLNWRIVVEK 298
            :.|.|..|...|...||:|::..|....:.....|..|..|             ||::..:
  Rat   273 KIAHLAGCDHNSTKIMVKCLKALPAEKVMLVSKKMTFFRANSHKDPKDIVWFLSPVVDGLV---- 333

  Fly   299 DFGQERYLIESPFKTARRGDFHKVALITGITEFEFLSGAFFDLR---NESIVNRYNRDWEHYASI 360
                   ..|.|.....||....|..:.|:...||.....|.::   |:.|:|: |...:...|.
  Rat   334 -------FPEDPVVLLTRGQVKPVPYLLGVNSAEFEWSLPFLMKLQLNQRIMNK-NYITKLLWSC 390

  Fly   361 ALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDA------LIGVSFHRFLQLM 419
            ::||.....|....:|    :|:.:::...::......:.:|:.||      |....:||
  Rat   391 SILLNITEEQIPLVAR----EYLSDAISHHDWKMFRNHLIDLVGDATFVYATLQAARYHR----- 446

  Fly   420 SPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLK---REDPENFMIEL 481
            ...:|:|.|.|::......:|    .::.|..|.|||.|||.    .|..|   |.:.:.|.:::
  Rat   447 DAGSPVYLYEFKHHAPGIIVK----PRSDGADHGDELSYLFG----SPFSKGSSRGEEKEFSLQM 503

  Fly   482 LTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLE------IGNNLTAKSGGFF 533
            : :.|..||..|||:::...|     ||.::.::| ||:      :|..|..|...|:
  Rat   504 M-KYWANFAHTGDPNDRELPY-----WPRFDKEEK-YLQLDFDTRVGVKLREKQMTFW 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	169/578 (29%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	76/190 (40%)
Ces4a	NP_001099646.1	COesterase	33..554	CDD:395084	162/558 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336414
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.900