Protein Alignment CG4757 and CES4A

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 636
• Identity: 174/636 - (27%)
• Similarity: 268/636 - (42%)
• Gaps: 158/636 - (24%)

  Fly    10 LVLLASSSVLSI-----EVDTELGRVRGANLTSRLG-VNFHAFRGIRYAEPPLGDLRFVNPQPVK 68
            |.|:|.:::.::     :|.|:.|.::|..:  .:| .....|.|:.::.||||.|||..|:|.:
Human    34 LCLMAQTALGALHTKRPQVVTKYGTLQGKQM--HVGKTPIQVFLGVPFSRPPLGILRFAPPEPPE 96

  Fly    69 PWSPKIFDASEDGP-----------------------------MCPQP------------WDNMT 92
            ||. .|.||:...|                             :.|||            |..:.
Human    97 PWK-GIRDATTYPPGWSLALSPGWSAVARSRLTATSASRVQASLLPQPLSIWGYRCLQESWGQLA 160

  Fly    93 DV-------------SEDCLRLNVYTKDL---KGRRPVIVFLHPGGFYVFSGQSKYLAGPEHFMD 141
            .:             |||||.||||....   ..:.||:|:. |||.::....|.| .|.:....
Human   161 SMYVSTRERYKWLRFSEDCLYLNVYAPARAPGDPQLPVMVWF-PGGAFIVGAASSY-EGSDLAAR 223

  Fly   142 RDCVLVSLNYRLGSLGFL----ATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYS 202
            ...|||.|.:|||..|||    .|....|.||.||.||:.||||:|::|..|||||.:|||.|.|
Human   224 EKVVLVFLQHRLGIFGFLRWRGRTDDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQS 288

  Fly   203 AGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAKRQAGLLKCPQESIGEMVECMR 267
            ||::|::..|:||::.|||||.|..|......:....|.|::||:.|.|..|...|...:|.|:|
Human   289 AGAMSISGLMMSPLASGLFHRAISQSGTALFRLFITSNPLKVAKKVAHLAGCNHNSTQILVNCLR 353

  Fly   268 RKPYLDYVSTYNGM-----------FEFGW--NPVLNWRIVVEKDFGQERYLIESPFKTARRGDF 319
            .......:...|.|           .|..|  :||:: .:|:..|          |.....:|..
Human   354 ALSGTKVMRVSNKMRFLQLNFQRDPEEIIWSMSPVVD-GVVIPDD----------PLVLLTQGKV 407

  Fly   320 HKVALITGITEFEF-----------LSGAFFDLRNESIVNRYNRDWEHYASIALLLEQNSTQSRA 373
            ..|..:.|:...||           |:..  .:|.|:|....   |    |...||  |.|:.:.
Human   408 SSVPYLLGVNNLEFNWLLPYIMKFPLNRQ--AMRKETITKML---W----STRTLL--NITKEQV 461

  Fly   374 ASRVFREKYMPESLDKLEYPKSLKGMGELLSDA------LIGVSFHRFLQLMSPHTPIYTYLFRY 432
            ...|  |:|: :::::.::......|.:::.||      |....:||...|     |:|.|.|.:
Human   462 PLVV--EEYL-DNVNEHDWKMLRNRMMDIVQDATFVYATLQTAHYHRDAGL-----PVYLYEFEH 518

  Fly   433 KGRYTFLKNPDNQQTIGPVHHDELIYL----FHVGLLIPLLKREDPENFMIELLTRMWIEFAQKG 493
            ..|...:|    .:|.|..|.||:.:|    |..||.:      ..|..:...:.:.|..||:.|
Human   519 HARGIIVK----PRTDGADHGDEMYFLFGGPFATGLSM------GKEKALSLQMMKYWANFARTG 573

  Fly   494 DPHNKNDEYLKGLNWPLYNAQDKGYLE------IGNNLTAKSGGFFLNRYQ 538
            :|::.|...     ||.|| :|:.||:      :|..|..|...|:::.||
Human   574 NPNDGNLPC-----WPRYN-KDEKYLQLDFTTRVGMKLKEKKMAFWMSLYQ 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	171/626 (27%)
CES4A	XP_011521323.1	COesterase	50..613	CDD:395084	168/613 (27%)