DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and Ces2a

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	179/588 - (30%)
Similarity:	270/588 - (45%)	Gaps:	101/588 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LFVVE--LLVLL----ASSSVLSIEVDTELGRVRGANL---TSRLGVNFHAFRGIRYAEPPLGDL 59
            |:||.  ||:||    ...|...|. :|..|:|||:.:   .::.|:  |.|.||.:|:||:|.|
  Rat    10 LYVVACGLLLLLQHVHGQDSASPIR-NTHTGQVRGSFVHVKDTKSGI--HTFLGIPFAKPPVGPL 71

  Fly    60 RFVNPQPVKPWSPKIFDASEDGPMCPQPWDNM--------------TDVSEDCLRLNVYT----- 105
            ||..|:..:||| .:.||:....||.|. |.|              |.:|||||.||:||
  Rat    72 RFAPPEDPEPWS-GVRDATSQPAMCLQT-DIMNLDGIKEMKLTVHPTPMSEDCLYLNIYTPAHAR 134

  Fly   106 --KDLKGRRPVIVFLHPGGFYVFS---GQSKYLAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKE 165
              .:|    ||:|::|.||..:.|   ..:..||..|     :.|:||:.||||.|||.:||.:.
  Rat   135 EGSNL----PVMVWIHGGGLVLGSASMNDASTLAATE-----EIVIVSIQYRLGVLGFFSTGDQN 190

  Fly   166 APGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAA 230
            |.||.|..|||.||||:||:|..|||:...||:.|.|||..||:.|::||||:||||..|..|..
  Rat   191 ARGNWGYLDQVAALRWVQQNIAYFGGNHGKVTIFGGSAGGTSVSSHVVSPMSKGLFHGAIMQSGV 255

  Fly   231 PYGPVKYKDNDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYVSTYNGMFEF--GWNPVLNWR 293
            ...|....|....:.|..|.|..|.......::.|:|.|...: :...|.:|:.  |
  Rat   256 ALLPDLISDKSEVVYKTVANLSGCEAPDSEALIRCLRAKSKQE-ILAINQVFKMIPG-------- 311

  Fly   294 IVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYA 358
             ||:     .::|.:.|.:....||||.|..|.||...|...|....|..:.|:.:..|:
  Rat   312 -VVD-----GKFLPKHPQELLASGDFHPVPSIIGINTDECGWGIPVFLGLDHIIKKITRE----- 365

  Fly   359 SIALLLEQNSTQSRAASR---VFREKYMPESLDKLEYPKSL-KGMGELLSDALIGVSFHRFLQLM 419
            ::..:|:..:.|......   :..|:||.::    |.|::| :....:|.|.:..:...:.....
  Rat   366 TLPTVLKSTAAQMMLPPECIDLIMEEYMGDT----ENPETLQEQFRHMLGDFMFVIPALQVAHFQ 426

  Fly   420 SPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHV---GLLIPLLKREDPENFMIEL 481
            ....|:|.|.|::...:.....|.:   :...|.|:::::|..   |:...|.:.|       ||
  Rat   427 RSQAPVYFYEFQHLPSFIKQVRPSH---VKADHGDDILFVFGSYLWGMTFDLTEEE-------EL 481

  Fly   482 LTR----MWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQIWED 542
            |.|    .|..||:.|:|   |.|.|.  :||:.: .|:.||:: |...|........|.|.|..
  Rat   482 LKRRVMKYWANFARTGNP---NGEDLP--HWPVLD-HDEQYLQL-NTQPAVGRALKARRLQFWTK 539

  Fly   543 LFP 545
            ..|
  Rat   540 TLP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	170/564 (30%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	77/187 (41%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	169/561 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336212
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.990