DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4757 and Nlgn3

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_766520.2	Gene:	Nlgn3 / 245537	MGIID:	2444609	Length:	825	Species:	Mus musculus

Alignment Length:	652	Identity:	176/652 - (26%)
Similarity:	268/652 - (41%)	Gaps:	178/652 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LVLLASSSVLSIEVDTELGRVRGAN--LTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSP 72
            |||.||:...:..|:|..|::|||.  |.|.:......:.|:.||.||:|:.||:.|:|...||
Mouse    28 LVLRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWS- 91

  Fly    73 KIFDASEDGPMCPQ------------PW---------DNMTDVSEDCLRLNVYT----------- 105
            .|.:|:...|:|||            .|         ..:.:.:||||.||||.
Mouse    92 GIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDGSGAKKQ 156

  Fly   106 -KDL-------------KGRRPVIVFLHPGGFYVFSGQSKYLAGPEHFMDRDCVLVSLNYRLGSL 156
             :||             .|.:||:|::| ||.|: .|....:.|.......:.::::||||:|.|
Mouse   157 GEDLADNDGDEDEDIRDSGAKPVMVYIH-GGSYM-EGTGNMIDGSVLASYGNVIVITLNYRVGVL 219

  Fly   157 GFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLF 221
            |||:||.:.|.||.||.||:.||||:.::|..|||||..:|:.|...|:..|:|..||..|.|||
Mouse   220 GFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLF 284

  Fly   222 HRGICMS-------AAPYGPVKYKDNDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYVSTYN 279
            .|.|..|       |..|.||||    ..|...:.|   |......:||:|:|:|
Mouse   285 QRAIIQSGSALSSWAVNYQPVKY----TSLLADKVG---CNVLDTVDMVDCLRQK---------- 332

  Fly   280 GMFEFGWNPVLNWRIVVEKDFGQERYLI------------ESPFKTARRGDFHKVALITGITEFE 332
                       :.:.:||:|....||.:            :.|.....:|:|....::.|:.:.|
Mouse   333 -----------SAKELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGE 386

  Fly   333 FL-------------SGAFFDLRNESIV-NRYNRDWEHYASIALLLEQNSTQSRAASRVFRE--K 381
            .|             ||..||....:.| |.|...           |...|        .||  |
Mouse   387 GLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYP-----------EGKDT--------LRETIK 432

  Fly   382 YMPESLDKLEYPKS-LKGMGELLSD------ALIGVSFH-RFLQLMSPHTPIYTYLFRYKGRYTF 438
            :|.......:.|:: .|.:..|.:|      :::....| |:      .:|.|.|.| |....:.
Mouse   433 FMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARY------GSPTYFYAF-YHHCQSL 490

  Fly   439 LKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKRED--PENF------MIELLTRMWIEFAQKGDP 495
            :|...:.    ..|.||:.|:|.|    |::...|  |.||      :..::...|..||:.|||
Mouse   491 MKPAWSD----AAHGDEVPYVFGV----PMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDP 547

  Fly   496 -----------HNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQIWEDLFP-LSS 548
                       |.|.:.: :.:.|..||.:|:.||.||.....:. .:...:...|:.|.| |.:
Mouse   548 NKPVPQDTKFIHTKANRF-EEVAWSKYNPRDQLYLHIGLKPRVRD-HYRATKVAFWKHLVPHLYN 610

  Fly   549 FH 550
            .|
Mouse   611 LH 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	167/634 (26%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	69/209 (33%)
Nlgn3	NP_766520.2	COesterase	39..601	CDD:365897	166/628 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..172		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..668
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832434
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740