DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4757 and Ces1c

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	XP_006255234.2	Gene:	Ces1c / 24346	RGDID:	2571	Length:	551	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	172/544 - (31%)
Similarity:	252/544 - (46%)	Gaps:	98/544 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VDTELGRVRG-----ANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGP 82
            |||..|:|.|     ...|..:.|    |.|:.:|:||||.|||..|:|.:||| .:.:.:...|
  Rat    28 VDTTKGKVLGKYVSLEGFTQPVAV----FLGVPFAKPPLGSLRFAPPEPAEPWS-FVKNTTTYPP 87

  Fly    83 MCPQPW--------------DNM-TDVSEDCLRLNVYT-KDL--KGRRPVIVFLHPGGFYVFSGQ 129
            ||.|..              :|: .:.|||||.||:|: .||  ..|.||:|::|.||. :..|.
  Rat    88 MCSQDGVVGKLLADMLSTGKENIPLEFSEDCLYLNIYSPADLTKNSRLPVMVWIHGGGL-IIGGA 151

  Fly   130 SKY--LAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGD 192
            |.|  ||...|   .:.|:|::.||||..|..:||.:.:.||....||:.||||:|.:|..|||:
  Rat   152 SPYSGLALSAH---ENVVVVTIQYRLGIWGLFSTGDEHSRGNWAHLDQLAALRWVQDNIANFGGN 213

  Fly   193 PDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAKRQAGLLKCPQE 257
            |||||:.|.|||.:||::.:|||:::.||||.|..|.........|.|...:|:..|.|..|...
  Rat   214 PDSVTIFGESAGGVSVSVLVLSPLAKNLFHRAISESGVVLTTNLDKKNTQAVAQMIATLSGCNNT 278

  Fly   258 SIGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIVVEKDFGQERYLIESPFKTARRGDFHKV 322
            |...||:|:|:|...:.:.....:.....:.|:: .:|:.|.  .|..|.|..|.|        |
  Rat   279 SSAAMVQCLRQKTEAELLELTVKLDNTSMSTVID-GVVLPKT--PEEILTEKSFNT--------V 332

  Fly   323 ALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMP--- 384
            ..|.|..:.||                   .|.....:..||.:.....:.||.:.| ::.|
  Rat   333 PYIVGFNKQEF-------------------GWIIPTMMGNLLSEGRMNEKMASSLLR-RFSPNLN 377

  Fly   385 --ESLDKLEYPKSLKGMG------ELLSDALIGVSFHRFLQLMS-----PHTPIYTYLFRYKGRY 436
              ||:......|.|:|..      |||.|....|.|.....|||     ...|.|.|.|:|:..:
  Rat   378 ISESVIPAIIEKYLRGTDDPAKKKELLLDMFSDVFFGIPAVLMSRSLRDAGAPTYMYEFQYRPSF 442

  Fly   437 TFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKR--EDPENFMIELLTRMWIEFAQKGDPHNKN 499
            ...:.|   ||:...|.||:..:|..    |.||.  .:.|..:.:|:.:.|..||:.|:|:.
  Rat   443 VSDQRP---QTVQGDHGDEIFSVFGT----PFLKEGASEEETNLSKLVMKFWANFARNGNPNG-- 498

  Fly   500 DEYLKGL-NWPLYNAQDKGYLEIG 522
                :|| :||.|: |.:|||:||
  Rat   499 ----EGLPHWPEYD-QKEGYLQIG 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	172/544 (32%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	73/183 (40%)
Ces1c	XP_006255234.2	COesterase	24..534	CDD:395084	172/544 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.970