DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and Cel

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_058693.2	Gene:	Cel / 24254	RGDID:	2331	Length:	612	Species:	Rattus norvegicus

Alignment Length:	582	Identity:	158/582 - (27%)
Similarity:	246/582 - (42%)	Gaps:	113/582 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MLFVVELLVLLASSSVLSIEVDTELGRVRGANLTSRL--GVNFHAFRGIRYAEPPLGDLRFVNPQ 65
            :||:.....|.|:.:.....|.||.|.|.|.|....|  |.:...|:||.:|...    ...|||
  Rat     6 VLFLGLTCCLAAACAAKLGAVYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAK----TLENPQ 66

  Fly    66 PVKPWSPKIFDASEDGPMCPQPWDNMTDV--SEDCLRLNVYTKDLKGRR------PVIVFLHPGG 122
            ....|...: .|::....|.|......|.  .||||.||::..  :||:      ||:|:::.|.
  Rat    67 RHPGWQGTL-KATDFKKRCLQATITQDDTYGQEDCLYLNIWVP--QGRKQVSHDLPVMVWIYGGA 128

  Fly   123 FYVFSGQ-----SKYLAGPEHFMDR-DCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRW 181
            |.:.|||     ..||...|....| :.::|:.|||:|.||||:||....|||.||:||.:|:.|
  Rat   129 FLMGSGQGANFLKNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNFGLRDQHMAIAW 193

  Fly   182 IQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAK 246
            ::::|..||||||::|:.|.|||:.||:|..|||.::||..|.|..|.....|...::|.|..||
  Rat   194 VKRNIAAFGGDPDNITIFGESAGAASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQENPLFWAK 258

  Fly   247 RQAGLLKCPQESIGEMVECMR-----------RKP----------YLDYVSTYNGMFEFGWNPVL 290
            ..|..:.||.|...:|..|::           |.|          ||.::...:|.| ...:|:.
  Rat   259 TIAKKVGCPTEDTAKMAGCLKITDPRALTLAYRLPLKSQEYPIVHYLAFIPVVDGDF-IPDDPIN 322

  Fly   291 NWRIVVEKDF-----GQERYL--------IESPFKTARRGDFHKVALITGITEFEFLSG--AFFD 340
            .:....:.|:     ..:.:|        |:...:.....||::  |::|.|..:.|.|  |.||
  Rat   323 LYDNAADIDYLAGINDMDGHLFATVDVPAIDKAKQDVTEEDFYR--LVSGHTVAKGLKGTQATFD 385

  Fly   341 LRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSD 405
            :        |...|          .|:.:|..          |.:::...|            :|
  Rat   386 I--------YTESW----------AQDPSQEN----------MKKTVVAFE------------TD 410

  Fly   406 ALIGVSFHRFLQLMSPH---TPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIP 467
            .|..:.....|.....|   ...|:|||.:..|.     |...:.:|..|.|:|.|:|......|
  Rat   411 ILFLIPTEMALAQHRAHAKSAKTYSYLFSHPSRM-----PIYPKWMGADHADDLQYVFGKPFATP 470

  Fly   468 LLKREDPENFMIELLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKS 529
            |..|.. :..:.:.:...|..||:.|||:..|...  ..:|..|..::..||:|...:|:.|
  Rat   471 LGYRAQ-DRTVSKAMIAYWTNFAKSGDPNMGNSPV--PTHWYPYTTENGNYLDINKKITSTS 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	154/570 (27%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	63/177 (36%)
Cel	NP_058693.2	COesterase	26..542	CDD:278561	154/562 (27%)
		Aes	<118..>247	CDD:223730	55/128 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..612
		4 X 11 AA tandem repeats, O-glycosylated region	556..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336383
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740