Protein Alignment CG4757 and CES3

DIOPT Version :9

• Sequence 1: NP_001262469.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_079198.2
• Gene: CES3 / 23491
• HGNCID: 1865
• Length: 571
• Species: Homo sapiens
• Alignment Length: 616
• Identity: 185/616 - (30%)
• Similarity: 271/616 - (43%)
• Gaps: 134/616 - (21%)

  Fly     2 LMLFVVELLVLLASSS----VLSIEVDTELGRVRGANL----TSRLGVNFHAFRGIRYAEPPLGD 58
            :::.||.||:...:::    |...||||.||||||..:    |.|| ||  .|.||.:|:||||.
Human    11 VLVGVVCLLLACPATATGPEVAQPEVDTTLGRVRGRQVGVKGTDRL-VN--VFLGIPFAQPPLGP 72

  Fly    59 LRFVNPQPVKPWSPKIFDASEDGPMCPQPWDNMT-------------DVSEDCLRLNVYTK---D 107
            .||..|.|.:||. .:.|||...|||.|..::|.             .||||||.||||:.   .
Human    73 DRFSAPHPAQPWE-GVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVP 136

  Fly   108 LKGRRPVIVFLHPGGFYVFSGQSKYLAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGL 172
            ....|||:|::|.|.  :.:|.:....|.......|.|:|::.||||.|||.:||.:.||||.|.
Human   137 AGSGRPVMVWVHGGA--LITGAATSYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGF 199

  Fly   173 KDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKY 237
            .|.|.||||:|::|..||||.:.||:.|.|||...::..:|||::.|||||.|..|.....|...
Human   200 LDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGII 264

  Fly   238 KDNDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIVVEKDFGQ 302
            ..:...||::.|..|.|...|..|||:|:::|.                    ...:|:.|....
Human   265 DSHPWPLAQKIANTLACSSSSPAEMVQCLQQKE--------------------GEELVLSKKLKN 309

  Fly   303 ERYLI--------ESPFKTARRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYAS 359
            ..|.:        :||.:..:...||.|..:.|:...||                   .|.....
Human   310 TIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEF-------------------SWLIPRG 355

  Fly   360 IALL--LEQNSTQSRAA-------SRVFREKYMPESLDKLEYPKS-------LKGMGELLSDALI 408
            ..||  :||.|.:...|       |.....:.||..:|  ||..|       .:...|.:.|..|
Human   356 WGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTVID--EYLGSNSDAQAKCQAFQEFMGDVFI 418

  Fly   409 G---VSFHRFLQLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPV-----HHDELIYLFHVGLL 465
            .   |||.|:|:  ...:|::.|.|:::        |.:...|.|.     |..|..::|....|
Human   419 NVPTVSFSRYLR--DSGSPVFFYEFQHR--------PSSFAKIKPAWVKADHGAEGAFVFGGPFL 473

  Fly   466 IPLLKR-------EDPENFMIELLTRMWIEFAQKGDPHNKNDEYLKGL-NWPLYNAQDKGYLEIG 522
            :....|       |:.:...:.::.: |..||:.|||::      |.| .||.:| |.:.||||
Human   474 MDESSRLAFPEATEEEKQLSLTMMAQ-WTHFARTGDPNS------KALPPWPQFN-QAEQYLEI- 529

  Fly   523 NNLTAKSGGFFLNRY-QIWEDLFP--LSSFH 550
             |...::|..|...: |.|.:..|  :..:|
Human   530 -NPVPRAGQKFREAWMQFWSETLPSKIQQWH 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	178/589 (30%)
		Aes	40..>204	CDD:223730	75/179 (42%)
CES3	NP_079198.2	COesterase	32..547	CDD:278561	177/581 (30%)
		Aes	<129..>247	CDD:223730	48/119 (40%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142616
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840