Protein Alignment CG4757 and Ces2b

DIOPT Version :9

• Sequence 1: NP_001262469.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_937814.1
• Gene: Ces2b / 234669
• MGIID: 2448547
• Length: 556
• Species: Mus musculus
• Alignment Length: 588
• Identity: 168/588 - (28%)
• Similarity: 265/588 - (45%)
• Gaps: 113/588 - (19%)

  Fly     2 LMLFVVELLVLLA-----SSSVLSIEVDTELGRVRGANL---TSRLGVNFHAFRGIRYAEPPLGD 58
            ::||  .||:||.     .|...|...:|..|:|||:.:   .::.||  |.|.||.:|:||:|.
Mouse    12 VLLF--GLLLLLGHVQGQDSPEASPIRNTHTGQVRGSLVHVKDTKAGV--HTFLGIPFAKPPVGP 72

  Fly    59 LRFVNPQPVKPWSPKIFDASEDGPMCPQPWDNMTDV---------SEDCLRLNVYT-------KD 107
            |||..|:..:||| .:.|.:....||.|....|.::         |||||.||:||       .:
Mouse    73 LRFAPPEAPEPWS-GVRDGTAHPAMCLQNLGVMKEIKLKLPPVSTSEDCLYLNIYTPAHAHEGSN 136

  Fly   108 LKGRRPVIVFLHPGGFYVFSGQSKYLAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGL 172
            |    ||:|::|.||  :.:|.:....|.......|.|:|::.||||.|||.:||.:.|.||.|.
Mouse   137 L----PVMVWIHGGG--LVAGMASMYDGSLLAAIEDLVVVTIQYRLGVLGFFSTGDQHARGNWGF 195

  Fly   173 KDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKY 237
            .|||.|||||||:|..|||.||.||:.|.|||..||:.|::||||:||||..|..|.....|...
Mouse   196 LDQVAALRWIQQNIAHFGGKPDRVTIFGESAGGTSVSSHVVSPMSKGLFHGAIMESGVALLPYLI 260

  Fly   238 KDNDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNW-RIVVEKDFG 301
            .|....::...|.|..|.......:|.|:|.|...:.::.         |.::.. ..||:.:|
Mouse   261 TDTSEMVSTTVAKLSGCEAMDSEALVRCLRGKSEAEILAI---------NKLVQMIPAVVDGEF- 315

  Fly   302 QERYLIESPFKTARRGDFHKVALITGITEFEF------LSGAFFDLRNESIVNRYNRDWEHYASI 360
                ....|.:.....|||.|..|.|:...||      :.|:...::.   :.|.|        :
Mouse   316 ----FPRHPKELLASEDFHPVPSIIGVNNDEFGWTIPVVMGSAQTIKE---ITREN--------L 365

  Fly   361 ALLLEQNSTQ---SRAASRVFREKYMPESLD----KLEYPKSLKGMGELLSDALIGVSFHRFLQL 418
            ..:|:..:.|   ....|.:..|:||.::.|    ::::.       |::.|.:..:...:....
Mouse   366 QAVLKNTTAQLMLPPECSDLLMEEYMGDTEDAQTLQIQFT-------EMMEDFMFVIPALQVAYF 423

  Fly   419 MSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVH----H-DELIYLFHVGLLIPLLKREDPENFM 478
            ...|..:|.|.|::  :...||:      :.|.|    | ||:.::|........|...:.|..:
Mouse   424 QRSHASVYFYEFQH--QIASLKD------VRPTHVKADHADEIPFVFGYFFWDMKLDFTEGEKLL 480

  Fly   479 IELLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLE------IGNNLTAKSGGFFLNRY 537
            ...:.:.|..||:.|:|:::...|     ||:.: .|:.||:      :|..|.::       |.
Mouse   481 SRRMMKYWANFARHGNPNSEGLPY-----WPVMD-HDEQYLQLDTQPAVGRALKSR-------RL 532

  Fly   538 QIW 540
            |.|
Mouse   533 QFW 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	161/568 (28%)
		Aes	40..>204	CDD:223730	76/179 (42%)
Ces2b	NP_937814.1	COesterase	34..535	CDD:365897	159/562 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832693
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3450
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.890