Protein Alignment CG4757 and NLGN1

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 683
• Identity: 166/683 - (24%)
• Similarity: 258/683 - (37%)
• Gaps: 237/683 - (34%)

  Fly    12 LLASSSVLSIEVD-------TELGRVRG--ANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPV 67
            ||.:..|||.::|       |..|::||  ..|.:.:......|.|:.||.||.|:.||..|:|.
Human    37 LLQAGHVLSQKLDDVDPLVATNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPP 101

  Fly    68 KPWSPKIFDASEDGPMCPQ-------------PW--DNM-------TDVSEDCLRLNVYT----- 105
            .||| .|.:|::..|:|||             .|  :|:       .|.|||||.||:|.
Human   102 SPWS-DIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDG 165

  Fly   106 ---------------------KDLKGRRPVIVFLHPGGFYVFSGQSKYLAGPEHFMD-------R 142
                                 :|..|.:||:|::|.|         .|:.|..:..|       .
Human   166 PLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGG---------SYMEGTGNLYDGSVLASYG 221

  Fly   143 DCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSIS 207
            :.:::::|||||.||||:||.:.|.||.||.|.:.||||..::|..|||||..:|:.|..||...
Human   222 NVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSC 286

  Fly   208 VALHMLSPMS---------RGLFHRGICMS-------AAPYGPVKYKDNDLQLAKRQAGLLKCPQ 256
            |.|..||..|         :|||.|.|..|       |..:.|.||       |:..|..:.|..
Human   287 VNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKY-------ARMLATKVGCNV 344

  Fly   257 ESIGEMVECMRRKPYLDYV--STYNGMFEFGWNPVLNWRIVVEKDFGQERYLIESPFKTARRGDF 319
            ....|:|||:::|||.:.|  ......:...:.||::..::.:    ..:.|:|       :|:|
Human   345 SDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVIPD----DPQILME-------QGEF 398

  Fly   320 HKVALITGI---------------------TEFEFLSGAFF----------DLRNESIVNRYNRD 353
            ....::.|:                     ::|:|....|.          |:..|:|...|. |
Human   399 LNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYT-D 462

  Fly   354 WEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGVSFHRFLQL 418
            |                        .:::.||:..|                        ..|.|
Human   463 W------------------------ADRHNPETRRK------------------------TLLAL 479

  Fly   419 MSPH-----------------TPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLI 466
            .:.|                 :|.|.|.|     |...:...........|.||:.|:    |.|
Human   480 FTDHQWVAPAVATADLHSNFGSPTYFYAF-----YHHCQTDQVPAWADAAHGDEVPYV----LGI 535

  Fly   467 PLLKRED--PENF------MIELLTRMWIEFAQKGDP-----------HNKNDEYLKGLNWPLYN 512
            |::...:  |.||      :..::...|..||:.|||           |.|.:.: :.:.|..|:
Human   536 PMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRF-EEVAWTRYS 599

  Fly   513 AQDKGYLEIGNNLTAKSGGFFLNRYQIWEDLFP 545
            .:|:.||.||.....|. .:..|:..:|.:|.|
Human   600 QKDQLYLHIGLKPRVKE-HYRANKVNLWLELVP 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	159/668 (24%)
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	157/661 (24%)