DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and NLGN1

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001352852.1	Gene:	NLGN1 / 22871	HGNCID:	14291	Length:	843	Species:	Homo sapiens

Alignment Length:	683	Identity:	166/683 - (24%)
Similarity:	258/683 - (37%)	Gaps:	237/683 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLASSSVLSIEVD-------TELGRVRG--ANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPV 67
            ||.:..|||.::|       |..|::||  ..|.:.:......|.|:.||.||.|:.||..|:|.
Human    37 LLQAGHVLSQKLDDVDPLVATNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPP 101

  Fly    68 KPWSPKIFDASEDGPMCPQ-------------PW--DNM-------TDVSEDCLRLNVYT----- 105
            .||| .|.:|::..|:|||             .|  :|:       .|.|||||.||:|.
Human   102 SPWS-DIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDG 165

  Fly   106 ---------------------KDLKGRRPVIVFLHPGGFYVFSGQSKYLAGPEHFMD-------R 142
                                 :|..|.:||:|::|.|         .|:.|..:..|       .
Human   166 PLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGG---------SYMEGTGNLYDGSVLASYG 221

  Fly   143 DCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSIS 207
            :.:::::|||||.||||:||.:.|.||.||.|.:.||||..::|..|||||..:|:.|..||...
Human   222 NVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSC 286

  Fly   208 VALHMLSPMS---------RGLFHRGICMS-------AAPYGPVKYKDNDLQLAKRQAGLLKCPQ 256
            |.|..||..|         :|||.|.|..|       |..:.|.||       |:..|..:.|..
Human   287 VNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKY-------ARMLATKVGCNV 344

  Fly   257 ESIGEMVECMRRKPYLDYV--STYNGMFEFGWNPVLNWRIVVEKDFGQERYLIESPFKTARRGDF 319
            ....|:|||:::|||.:.|  ......:...:.||::..::.:    ..:.|:|       :|:|
Human   345 SDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVIPD----DPQILME-------QGEF 398

  Fly   320 HKVALITGI---------------------TEFEFLSGAFF----------DLRNESIVNRYNRD 353
            ....::.|:                     ::|:|....|.          |:..|:|...|. |
Human   399 LNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYT-D 462

  Fly   354 WEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGVSFHRFLQL 418
            |                        .:::.||:..|                        ..|.|
Human   463 W------------------------ADRHNPETRRK------------------------TLLAL 479

  Fly   419 MSPH-----------------TPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLI 466
            .:.|                 :|.|.|.|     |...:...........|.||:.|:    |.|
Human   480 FTDHQWVAPAVATADLHSNFGSPTYFYAF-----YHHCQTDQVPAWADAAHGDEVPYV----LGI 535

  Fly   467 PLLKRED--PENF------MIELLTRMWIEFAQKGDP-----------HNKNDEYLKGLNWPLYN 512
            |::...:  |.||      :..::...|..||:.|||           |.|.:.: :.:.|..|:
Human   536 PMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRF-EEVAWTRYS 599

  Fly   513 AQDKGYLEIGNNLTAKSGGFFLNRYQIWEDLFP 545
            .:|:.||.||.....|. .:..|:..:|.:|.|
Human   600 QKDQLYLHIGLKPRVKE-HYRANKVNLWLELVP 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	161/673 (24%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	70/218 (32%)
NLGN1	NP_001352852.1	COesterase	53..626	CDD:365897	157/660 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142637
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740