Protein Alignment CG4757 and NLGN4Y

DIOPT Version :9

• Sequence 1: NP_001262469.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 643
• Identity: 167/643 - (25%)
• Similarity: 276/643 - (42%)
• Gaps: 151/643 - (23%)

  Fly     2 LMLFVVELLV---LLASSSVLSIEVDTELGRVRGAN--LTSRLGVNFHAFRGIRYAEPPLGDLRF 61
            ::|::..|.:   |:.|.:...: |:|..|:::|..  |.|.:......:.|:.||.||.|:.||
Human    25 VLLWITALAIKFTLIDSQAQYPV-VNTNYGKIQGLRTPLPSEILGPVEQYLGVPYASPPTGERRF 88

  Fly    62 VNPQPVKPWSPKIFDASEDGPMCPQPWDN-------------------MT---DVSEDCLRLNVY 104
            ..|:....|: .|.:|::...:|||..|.                   ||   |.:||||.||:|
Human    89 QPPESPSSWT-GIRNATQFSAVCPQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIY 152

  Fly   105 T-----------------------KDL---KGRRPVIVFLHPGGFYVFSGQSKYLAGPEHFMD-- 141
            .                       ||:   ..::||:|::|.|         .|:.|..:.:|
Human   153 VPMEDGTNIKRNADDITSNDHGEDKDIHEQNSKKPVMVYIHGG---------SYMEGTGNMIDGS 208

  Fly   142 -----RDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGY 201
                 .:.:::::|||||.||||:||.:.|.||.||.||:.|||||::::..|||||..||:.|.
Human   209 ILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGS 273

  Fly   202 SAGSISVALHMLSPMSRGLFHRGICMS-------AAPYGPVKYKDNDLQLAKRQAGLLKCPQESI 259
            .||:..|:|..||..|.|||.:.|..|       |..|.|.||       .:..|..:.|.....
Human   274 GAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKY-------TRILADKVGCNMLDT 331

  Fly   260 GEMVECMRRKPYLDYV------STYNGMFEFGWNPVLNWRIVVEKDFGQERYLIESPFKTARRGD 318
            .:||||::.|.|.:.:      :||:  ..||  ||::..::.:    ..:.|:|       :|:
Human   332 TDMVECLKNKNYKELIQQTITPATYH--IAFG--PVIDGDVIPD----DPQILME-------QGE 381

  Fly   319 FHKVALITGITEFEFLSGAFFD--LRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFRE- 380
            |....::.|:.:.|.|.  |.|  :.||..|...:.|:    |::..:: |...........||
Human   382 FLNYDIMLGVNQGEGLK--FVDGIVDNEDGVTPNDFDF----SVSNFVD-NLYGYPEGKDTLRET 439

  Fly   381 -KYMPESLDKLEYPKS-LKGMGELLSD------ALIGVSFHRFLQLMSPHTPIYTYLFRYKGRYT 437
             |:|.......|.|:: .|.:..|.:|      |:.....|  .|..||     ||.:.:   |.
Human   440 IKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLH--AQYGSP-----TYFYAF---YH 494

  Fly   438 FLKNPDNQQTIGPVHHDELIYLFHVGLLIP--LLKREDPEN--FMIELLTRMWIEFAQKGDP--- 495
            ..::..........|.||:.|:|.:.::.|  |......:|  .:..::...|..||:.|||
Human   495 HCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQP 559

  Fly   496 --------HNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQIWEDLFP 545
                    |.|.:.: :.:.|..||.:|:.||.||.....:. .:...:...|.:|.|
Human   560 VPQDTKFIHTKPNRF-EEVAWSKYNPKDQLYLHIGLKPRVRD-HYRATKVAFWLELVP 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	161/620 (26%)
		Aes	40..>204	CDD:223730	67/218 (31%)
NLGN4Y	NP_001352513.1	COesterase	46..610	CDD:306613	160/615 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142812
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840