DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4757 and Tg

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	XP_006520808.2	Gene:	Tg / 21819	MGIID:	98733	Length:	2767	Species:	Mus musculus

Alignment Length:	600	Identity:	162/600 - (27%)
Similarity:	244/600 - (40%)	Gaps:	171/600 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SSVLSIEVDTELGRVRGANLTSRLGV---NFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDA 77
            :|..|:.:|: .|:::|.:...::|.   ..:.|.|:.||.|||.|.||..|: |..|:.. :||
Mouse  2195 TSTPSVRIDS-FGQLQGGSQVIKVGTAWKQVYRFLGVPYAAPPLADNRFRAPE-VLNWTGS-WDA 2256

  Fly    78 SEDGPMCPQPWDNM---TDVSEDCLRLNVYT-KDLKGRRPVIVFLH-------PGGFYVFSGQSK 131
            ::....|.||....   ..::||||.|||:. ::|.....|:||.|       .||.....|  .
Mouse  2257 TKPRASCWQPGTRTPTPPQINEDCLYLNVFVPENLVSNASVLVFFHNTMEMEGSGGQLTIDG--S 2319

  Fly   132 YLAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSV 196
            .||...:|     ::|:.|||||..|||::||.|..||.||.|||.||.|:|.||..|||||..|
Mouse  2320 ILAAVGNF-----IVVTANYRLGVFGFLSSGSDEVAGNWGLLDQVAALTWVQSHIGAFGGDPQRV 2379

  Fly   197 TLLGYSAGSISVALHML--SPMSRGLFHRGICMS------AAPYGPVKYKDNDLQLAKRQAGLLK 253
            ||....:|:...::|:|  .|....||.:.:.|.      ||...|.:.:.....|||.    :.
Mouse  2380 TLAADRSGADVASIHLLISRPTRLQLFRKALLMGGSALSPAAIISPERAQQQAAALAKE----VG 2440

  Fly   254 CPQESIGEMVECMRRKP--YLDYVST----YNGMFEFGWNPVLNWRIVVEKDFGQERYLIESPFK 312
            ||..||.|:|.|:|:||  .|:...|    .:|.|.: |.||::         ||  ||.|.|.:
Mouse  2441 CPTSSIQEVVSCLRQKPANILNDAQTKLLAVSGPFHY-WGPVVD---------GQ--YLRELPSR 2493

  Fly   313 TARRGDFHKVALITG-------------ITEFEFLSG------AFFDLRNESIVNRYNRD----- 353
            ..:|....||.|:.|             :.:||...|      ||:.....|:... :.|
Mouse  2494 RLKRPLPVKVDLLIGGSQDDGLINRAKAVKQFEESQGRTNSKTAFYQALQNSLGGE-DSDARILA 2557

  Fly   354 ---W----EH----YASIALLLEQNSTQS----------------RAASRVFREKYMPESLDKLE 391
               |    ||    |||.:..|| |:|:.                |....||. .::|||..
Mouse  2558 AAVWYYSLEHSTDDYASFSRALE-NATRDYFIICPMVNMASLWARRTRGNVFM-YHVPESYG--- 2617

  Fly   392 YPKSLKGMGELLSDALIGVSFHRFLQLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDEL 456
                 .|..|||:|.......           |.|:   .|:|:::     ..:|::.
Mouse  2618 -----HGSLELLADVQYAFGL-----------PFYS---AYQGQFS-----TEEQSLS------- 2651

  Fly   457 IYLFHVGLLIPLLKREDPENFMIELLTRMWIEFAQKGDPHNKNDEYLKGLN----WP--LYNAQD 515
                        ||           :.:.:..|.:.|:|:..::...|...    ||  :..|..
Mouse  2652 ------------LK-----------VMQYFSNFIRSGNPNYPHEFSRKAAEFATPWPDFIPGAGG 2693

  Fly   516 KGYLEIGNNLTAKSG 530
            :.|.|:...|..:.|
Mouse  2694 ESYKELSAQLPNRQG 2708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	161/599 (27%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	70/177 (40%)
Tg	XP_006520808.2	TY	34..93	CDD:238114
		TY	96..161	CDD:238114
		TY	301..359	CDD:238114
		TY	<612..658	CDD:238114
		TY	661..726	CDD:238114
		TY	730..>776	CDD:381826
		TY	<893..922	CDD:381826
		TY	1005..1074	CDD:238114
		TY	1150..1211	CDD:238114
		Ephrin_rec_like	1464..1509	CDD:311571
		TY	1519..1566	CDD:214561
		COesterase	2198..2717	CDD:365897	160/596 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832900
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930