Protein Alignment CG4757 and Nlgn2

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_942562.2
• Gene: Nlgn2 / 216856
• MGIID: 2681835
• Length: 836
• Species: Mus musculus
• Alignment Length: 644
• Identity: 174/644 - (27%)
• Similarity: 264/644 - (40%)
• Gaps: 191/644 - (29%)

  Fly    23 VDTELGRVRGA--NLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMCP 85
            |:|..|||||.  .|.:.:......|.|:.||.||||..||..|:....| |.:.:|:...|.||
Mouse    44 VNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASW-PGVRNATTLPPACP 107

  Fly    86 Q------------PW--DNM-------TDVSEDCLRLNVY--------TK------------DLK 109
            |            .|  ||:       .:.|||||.||:|        ||            |::
Mouse   108 QNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIR 172

  Fly   110 --GRRPVIVFLHPGGFYVFSGQSKYLAGPEHFMD-------RDCVLVSLNYRLGSLGFLATGSKE 165
              |::||::|||.|         .|:.|..:..|       .:.::|:||||||.||||:||.:.
Mouse   173 DSGKKPVMLFLHGG---------SYMEGTGNMFDGSVLAAYGNVIVVTLNYRLGVLGFLSTGDQA 228

  Fly   166 APGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMS-- 228
            |.||.||.||:.||||:.::|..|||||:.:|:.|..||:..|.|.:||..|.|||.:.|..|
Mouse   229 AKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGT 293

  Fly   229 -----AAPYGPVKYKDNDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYV--STYNGMFEFGW 286
                 :..|.|:||       .:..|..:.|.:|...|.|||:|||...:.|  ......:...:
Mouse   294 AISSWSVNYQPLKY-------TRLLAAKVGCDREDSTEAVECLRRKSSRELVDQDVQPARYHIAF 351

  Fly   287 NPVLNWRIVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFEFL-------------SGAF 338
            .||::..:|.           :.|....::|:|....::.|:.:.|.|             |.:.
Mouse   352 GPVVDGDVVP-----------DDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASA 405

  Fly   339 FDLRNESIV-NRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGM--- 399
            ||....:.| |.|.                               .||..|.|.  :::|.|
Mouse   406 FDFTVSNFVDNLYG-------------------------------YPEGKDVLR--ETIKFMYTD 437

  Fly   400 ------GELLSDALIGV-SFHRFLQLMSP-----------HTPIYTYLFRYKGRYTFLKNPDNQQ 446
                  ||:....|:.: :.|   |.::|           .:|:|.|.|     |...:.....:
Mouse   438 WADRDNGEMRRKTLLALFTDH---QWVAPAVATAKLHADYQSPVYFYTF-----YHHCQAEGRPE 494

  Fly   447 TIGPVHHDELIYLFHVGLLIPLLKRED--PENF------MIELLTRMWIEFAQKGDP-------- 495
            .....|.|||.|:|.|    |::...|  |.||      :..::...|..||:.|||
Mouse   495 WADAAHGDELPYVFGV----PMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDT 555

  Fly   496 ---HNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQIWEDLFP-LSSFH 550
               |.|.:.: :.:.|..:|:::|.||.||.....:. .:..|:...|.:|.| |.:.|
Mouse   556 KFIHTKPNRF-EEVVWSKFNSKEKQYLHIGLKPRVRD-NYRANKVAFWLELVPHLHNLH 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	169/631 (27%)
Nlgn2	NP_942562.2	COesterase	42..601	CDD:395084	169/631 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836