DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and Ces2e

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	173/567 - (30%)
Similarity:	262/567 - (46%)	Gaps:	105/567 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DTELGRVRGANL---TSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMCP 85
            :|..|:|||:.:   .::.||  |.|.||.:|:||:|.|||..|:|.:||| .:.|.:....||.
  Rat    35 NTHTGQVRGSFVHVKDTKSGV--HTFLGIPFAKPPIGPLRFAPPEPPEPWS-GVRDGTSHPAMCL 96

  Fly    86 QPWDNM-------------TDVSEDCLRLNVYT-----KDLKGRRPVIVFLHPGGFYVFSGQSKY 132
            |..|.:             ..:|||||.|::||     ||  ...||:|::|.||. .:...|.|
  Rat    97 QNIDGLNLENLKIKMSRSPVSMSEDCLYLSIYTPAHTHKD--SNLPVMVWIHGGGL-CWGMASTY 158

  Fly   133 ----LAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDP 193
                ||..|     |.|:|::.||||.|||.:||.:.|.||.|..|||.||||:||:|..|||:|
  Rat   159 DGSMLAAIE-----DVVVVTIQYRLGILGFFSTGDEHARGNWGYLDQVAALRWVQQNIVHFGGNP 218

  Fly   194 DSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAKRQAGLLKCPQES 258
            |.||:.|.|||.|||:.|::||||:||||..|..|.....|....:....:....|.|..|....
  Rat   219 DRVTIFGESAGGISVSSHVVSPMSQGLFHGAIMESGVALLPNLISNTSEVIYTMVANLSGCEPVD 283

  Fly   259 IGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIVVEKDFG--QERYLIESPFKTARRGDFHK 321
            ...::.|:|.|...:.::..|               :|....|  ..::|...|.:.....|||.
  Rat   284 SEALMSCLREKSEEEMLAINN---------------IVRTISGVVDGKFLPRHPLELLASVDFHP 333

  Fly   322 VALITGITEFEFLSGAFFD-LRNESIVNRYNRDWEHYASIALLLEQNSTQSR---AASRVFREKY 382
            |..|.||...|:  |.... |..:|.:...||:     ::..:|:..:.|..   ..|.:..|:|
  Rat   334 VPSIIGINSDEY--GWIIPMLHPDSTMKEINRE-----TMRAVLKNTAVQMMLPPECSDLLMEEY 391

  Fly   383 MPESLDKLEYPKSLK-GMGELLSDALIGVSFHRFLQLMSPHTPIYTYLFRYKGRYTFLKNPDNQQ 446
            |.::.|.    |:|: ...|::.|.:..:...:.......|.|:|.|.|:::.  .|||:
  Rat   392 MGDTEDS----KTLQIQFNEMMGDFIFVIPALQVAHFQRSHAPVYFYEFQHQS--NFLKD----- 445

  Fly   447 TIGPVH----H-DELIYLFHVGLLIPLLK--REDPENFMIELLTRMWIEFAQKGDPHNKNDEYLK 504
             |.|.|    | |||.|:  :|.|...:|  ..:.|..:...:.:.|..||:.|:|:::...|
  Rat   446 -IRPPHVKADHGDELPYV--IGYLFWDMKFVFTEEEKLLSRKMIKYWANFARHGNPNSEGLPY-- 505

  Fly   505 GLNWPLYNAQDKGYLE------IGNNLTAKSGGFFLNRYQIWEDLFP 545
               ||..: .|:.||:      :|..|.|:       |.:.|....|
  Rat   506 ---WPALD-HDEQYLQLDIQPVVGRALKAR-------RLKFWTKTLP 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	171/560 (31%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	79/185 (43%)
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	171/560 (31%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	51/110 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336297
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.890