Protein Alignment CG4757 and Nlgn1

DIOPT Version :9

• Sequence 1: NP_001262469.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: XP_006535478.1
• Gene: Nlgn1 / 192167
• MGIID: 2179435
• Length: 863
• Species: Mus musculus
• Alignment Length: 703
• Identity: 168/703 - (23%)
• Similarity: 261/703 - (37%)
• Gaps: 257/703 - (36%)

  Fly    12 LLASSSVLSIEVD-------TELGRVRG--ANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPV 67
            ||.:..|||.::|       |..|::||  ..|.:.:......|.|:.||.||.|:.||..|:|.
Mouse    37 LLQTFHVLSQKLDDVDPLVTTNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPP 101

  Fly    68 KPWSPKIFDASEDGPMCPQ-------------PW--DNM-------TDVSEDCLRLNVY--TKDL 108
            .||| .|.:|::..|:|||             .|  :|:       .|.|||||.||:|  |:|:
Mouse   102 SPWS-DIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDV 165

  Fly   109 K--------------------------------------------GRRPVIVFLHPGGFYVFSGQ 129
            |                                            |.:||:|::|.|
Mouse   166 KRISKECARKPGKKICRKGGPLTKKHTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGG-------- 222

  Fly   130 SKYLAGPEHFMD-------RDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQ 187
             .|:.|..:..|       .:.:::::|||||.||||:||.:.|.||.||.|.:.||||..::|.
Mouse   223 -SYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIG 286

  Fly   188 RFGGDPDSVTLLGYSAGSISVALHMLSPMS---------RGLFHRGICMS-------AAPYGPVK 236
            .|||||..:|:.|..||...|.|..||..|         :|||.|.|..|       |..:.|.|
Mouse   287 FFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAK 351

  Fly   237 YKDNDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYV--STYNGMFEFGWNPVLNWRIVVEKD 299
            |       |:..|..:.|......|:|||:::|||.:.|  ......:...:.||::..::.:
Mouse   352 Y-------ARILATKVGCNVSDTVELVECLQKKPYKELVDQDVQPARYHIAFGPVIDGDVIPD-- 407

  Fly   300 FGQERYLIESPFKTARRGDFHKVALITGI---------------------TEFEFLSGAFF---- 339
              ..:.|:|       :|:|....::.|:                     ::|:|....|.
Mouse   408 --DPQILME-------QGEFLNYDIMLGVNQGEGLKFVENIVDSDDGVSASDFDFAVSNFVDNLY 463

  Fly   340 ------DLRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKG 398
                  |:..|:|...|. ||                        .:::.||:..|
Mouse   464 GYPEGKDVLRETIKFMYT-DW------------------------ADRHNPETRRK--------- 494

  Fly   399 MGELLSDALIGVSFHRFLQLMSPH-----------------TPIYTYLFRYKGRYTFLKNPDNQQ 446
                           ..|.|.:.|                 :|.|.|.|     |...:......
Mouse   495 ---------------TLLALFTDHQWVAPAVATADLHSNFGSPTYFYAF-----YHHCQTDQVPA 539

  Fly   447 TIGPVHHDELIYLFHVGLLIPLLKRED--PENF------MIELLTRMWIEFAQKGDP-------- 495
            .....|.||:.|:    |.||::...:  |.||      :..::...|..||:.|||
Mouse   540 WADAAHGDEVPYV----LGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDT 600

  Fly   496 ---HNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQIWEDLFP 545
               |.|.:.: :.:.|..|:.:|:.||.||.....|. .:..|:..:|.:|.|
Mouse   601 KFIHTKPNRF-EEVAWTRYSQKDQLYLHIGLKPRVKE-HYRANKVNLWLELVP 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	163/693 (24%)
		Aes	40..>204	CDD:223730	72/238 (30%)
Nlgn1	XP_006535478.1	COesterase	53..646	CDD:365897	159/680 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832519
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740