DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and cest-31

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_504692.3	Gene:	cest-31 / 187304	WormBaseID:	WBGene00019653	Length:	541	Species:	Caenorhabditis elegans

Alignment Length:	563	Identity:	154/563 - (27%)
Similarity:	249/563 - (44%)	Gaps:	95/563 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMCPQP 87
            :::..|.|:| ||........|.:.||.||:||:|.|||..|.....|: :..|.::.||.||..
Worm    17 LNSTCGPVQG-NLYRHGNEEVHGYLGIPYAQPPIGILRFKKPVSADVWT-ETRDCTKYGPRCPPS 79

  Fly    88 ---WDNM----TDVSED--CLRLNVYTK--DLK--GRRPVIVFLHPGGFYVFSGQSKYLAGPEHF 139
               ::|:    ||:.::  ||.|||:..  ::|  .:.||::|:|.|||        .|:..:.:
Worm    80 GMLYENLQLPNTDIPDEANCLSLNVFCPQWEIKQSAKHPVMIFIHGGGF--------ELSASKDY 136

  Fly   140 MD---------RDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDS 195
            .|         :|.::|::|||:|:||||.||.....||.||.|..|||:|:..||..|||||.:
Worm   137 CDYSLSGTLPLKDVIVVTVNYRVGALGFLTTGDDSCRGNFGLWDLTLALKWVSTHISSFGGDPKN 201

  Fly   196 VTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGP--VKYKDNDLQLAKRQAGLLKCPQES 258
            |||.|.|||::...|..|||.||.|||:.|.||.:.:.|  ::.::|...:....|.........
Worm   202 VTLFGQSAGAVCADLLNLSPYSRDLFHKLIIMSGSAHVPFAIRTEENQALVCMEYARSRGFSGSG 266

  Fly   259 IGEMVECMRRKPYLDYVSTYNGM-----FEFGWNPVLNWRIVVEKDFGQERYLIESPFKTARRGD 318
            ..|::|.....| ::.:....|:     .:..:.|.|      :.||      ...|.:..|| :
Worm   267 SAELLEFFENLP-IEKLLEKTGLKHTVSIDLSFAPNL------DGDF------FPKPLEELRR-E 317

  Fly   319 FHKVALITGITEFEFLSGAFFDLRNESIVNRYNR--DWEHYASIALLLEQNSTQSRAASRVFREK 381
            ..|..:|.|:.|.|.|..||.|....:....:.|  :.|:...:.    :|....:.....|...
Worm   318 TRKKPVIVGMMEDEGLITAFADGDFTTCEENFKRRVESEYRGDVV----ENPENVQKNIMNFYTN 378

  Fly   382 YMPESLDK--LEY-PKSLKGMGELLSDALIGVSFHRFLQLMSPHTPIYTYLFRYKGRYTFLKNPD 443
            |..||.::  ::| ..|:...|.|||..          .|......:|.|:|.:       .|||
Worm   379 YCDESEERKLVDYIGHSVYNAGVLLSAE----------SLARAGNCVYFYVFDF-------WNPD 426

  Fly   444 NQQTIGPV-------HHDELIYLFHVGLLIPLLKREDPENFMIELLTRMWIEFAQKGDPHNKNDE 501
            ....:|.:       |..||.|:...| :.......:.:..|:|.:|.|:..||:.|:|:
Worm   427 GFGPVGSIVPFKGAAHCSELRYIIGEG-VYSKFDANEKDLKMMEYMTTMFTNFAKYGNPN----- 485

  Fly   502 YLKGL-NWPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQIWEDL 543
             :.|: ||..| .:...:..|.:..:.....|..||.|..:.:
Worm   486 -IPGVTNWETY-TEGSRHFHIDSTDSEMKDSFQENRCQFLKQI 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	154/558 (28%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	69/185 (37%)
cest-31	NP_504692.3	COesterase	16..522	CDD:278561	153/557 (27%)
cest-31	NP_504692.3	Aes	<112..>211	CDD:223730	44/106 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820