Protein Alignment CG4757 and cest-7

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001257187.1
• Gene: cest-7 / 182819
• WormBaseID: WBGene00007693
• Length: 606
• Species: Caenorhabditis elegans
• Alignment Length: 598
• Identity: 149/598 - (24%)
• Similarity: 244/598 - (40%)
• Gaps: 158/598 - (26%)

  Fly     2 LMLFVVELLVLLASSSVLSIEV-DTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQ 65
            :..:.:.||.|    ||.|.:| :|..|:|||....|....:.:.|:||.:|:||||.|||..|:
 Worm    22 IFFYTLALLAL----SVKSFKVLNTNYGKVRGITDFSDKRNHKYIFKGIPFAKPPLGLLRFALPE 82

  Fly    66 PVKPWSPKIFDASEDGPMCPQPWDNMT-------DVSEDCLRLNVYTKD--LKGRRPVIVFLHPG 121
            ....|: .:.|.|:....|   ..|.:       ::|||||.:|::|.:  |..:.||:|:.|.|
 Worm    83 EPNTWN-GVLDGSKYSAAC---LSNSSLASAQQENISEDCLYINIFTSEYCLAHKCPVLVYYHGG 143

  Fly   122 GFYVFSG---QSKYLAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKE-APGNAGLKDQVLALRWI 182
            .|.:.|.   ..|::.  |.::|...|.....||||..|....|.:. .|.|..:.|.:.:|.::
 Worm   144 SFNLDSATMFPDKFIL--ERYVDSGIVFAIPAYRLGVFGQFYLGEQGIVPANLLIHDCIRSLNFV 206

  Fly   183 QQHIQRFGGDPDSVTLLGYSAGSISVAL----HMLSPMSRGLFHRGICMSA-APYGPVKYKD--- 239
            ..:|..|||||:.|||:|:|:|...|..    :.:.| .:.||.:.|.:|: ..||   ::|
 Worm   207 HDNIASFGGDPNYVTLMGHSSGGQLVNAMGFSNQIDP-EKKLFQQFIVLSSIGMYG---FEDLQI 267

  Fly   240 -NDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIVVE----KD 299
             |..::|:|.    .|..|:..|:|:|||....|..:.|...|.:.   .:|.::.::.    .|
 Worm   268 GNSYEIARRH----NCTSENSQEIVDCMRNIDALQLLQTQTVMDDV---DLLFFKAIIRAPPLMD 325

  Fly   300 FGQERYLIESPFK---TARRGDFHKVALITGITEFEF----------LSGAFFDLRNE-SIVNRY 350
            ..|:.    |.||   |||.       ::.|:|:.||          :|..|.|..|. ..||.|
 Worm   326 VKQKL----SEFKENVTARN-------MLCGVTDNEFTIFKYPDGYYISATFLDFENPVDTVNVY 379

  Fly   351 NRDWEHYA-------SIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDALI 408
            ...:.:..       |.|:.:.. :|.|.|.:......|:.||..|   |.|:.     ::|...
 Worm   380 RNKFTNITPTFVNSDSSAVFVSA-ATYSEALTNAGGNVYLFESRQK---PFSMH-----VTDMQY 435

  Fly   409 GVSFHRFLQLMSPHTPIYTYLFRYKGR----YTFLKNP-------------------DNQQTIGP 450
            .:..||    ...||.....|..:..:    :|...:|                   |.:|.|.|
 Worm   436 FIGIHR----EKNHTTDMDILDSFYSKLLVNFTKFGSPSPNWEKYDPSKMNFMAMEIDTEQGIEP 496

  Fly   451 V----HHDELIYLF--------------------------------HVGL--LIPLLKR---EDP 474
            .    .|:||:..:                                |:|:  .:|::..   .||
 Worm   497 KMENGFHEELVNFWLINMMQIDRNIIEMKLNGEYNSFDGRAQLTTKHIGVPTSLPIIYAPAVSDP 561

  Fly   475 ENF-MIELLTRMW 486
            ||. :|.:|.:.|
 Worm   562 ENLELISVLNQWW 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	144/580 (25%)
cest-7	NP_001257187.1	alpha/beta hydrolases	38..510	CDD:473884	133/512 (26%)