Protein Alignment CG4757 and cest-13

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_741921.1
• Gene: cest-13 / 181493
• WormBaseID: WBGene00010116
• Length: 548
• Species: Caenorhabditis elegans
• Alignment Length: 547
• Identity: 145/547 - (26%)
• Similarity: 234/547 - (42%)
• Gaps: 107/547 - (19%)

  Fly     2 LMLFVVELLVLLASSSVLS-----IEVDTELG--RVRGANLTSRLGVNFHAFRGIRYAEPPLGDL 59
            :.|..|..|:||..:|||:     :.|.|..|  .:||...|  .|.   :|||||||:||:|..
 Worm     1 MKLLSVSCLLLLHFASVLADPTYDVTVQTPNGSATIRGIQHT--YGT---SFRGIRYAQPPVGLF 60

  Fly    60 RFVNPQPVKPWSPKIFDASEDGPMCPQPWDNMTDVSEDCLRLNVYTKD---LKGRRPVIVFLHPG 121
            ||...:.:.|..  :.:|...|.:|.| .|..|. .||||.:||||.:   ...:.||.|::|.|
 Worm    61 RFGAARRLDPVG--LVEAQAYGNICVQ-GDGRTS-HEDCLFINVYTPNNVTQASKLPVYVYIHGG 121

  Fly   122 GFYVFSGQSKYLAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHI 186
            ||....|.......|........|:||:|||||..||.:|....||||..:.|.:.||.|:|::|
 Worm   122 GFVEGGGNMGAGIYPNLVNKGPIVMVSINYRLGPFGFFSTRQMTAPGNWAISDWIEALNWVQRYI 186

  Fly   187 QRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGP--VKYKDNDLQLAKRQA 249
            ..|||||:.||:.|.|:|:.:|:...|:|:::.||.:.|..|.:.:|.  :.|.:.....:|:.:
 Worm   187 SFFGGDPNRVTIGGQSSGAEAVSTLTLTPLAKNLFKQSIHESGSAFGAAVMSYSEKTRSTSKQLS 251

  Fly   250 GLLKCPQ-------ESIGEMVECMRRKPYLDYVSTYNGMFEFGWNP--VLNWRIVVEKDFGQER- 304
            ..|.|..       :|.|.::.|:|...|...|:..|.:      |  .:.|.||.:..:..:|
 Worm   252 IKLGCATSDQWDNGQSFGTILTCLRNVTYDKIVAADNSL------PGHRMKWSIVQDNKYLTQRL 310

  Fly   305 -YLI--ESPFKTARRGDFHKVALITGITEFEFLSGAFFDLRN--ESIVNRYN-----RD------ 353
             ||.  ..|.|....||.|.          |:|.   :::.|  .:|.:.:|     ||
 Worm   311 EYLALQRDPKKNVLIGDVHD----------EWLG---WEMNNVLHNINSSHNTAHQMRDDLSGSY 362

  Fly   354 ----WEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGVSFHR 414
                |::..|:.:..:.....::..:   .:.:......:::....:..:|..|.||    ::.:
 Worm   363 EMTYWDNKQSVLVAADNKYINNQGWT---DDNHREWEARRIQLWSEMVFIGPTLRDA----AYFQ 420

  Fly   415 FLQ----------LMSPHTPIYT-YLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPL 468
            :::          |..|..|:.| .|||                 |..|..||.|:|........
 Worm   421 YMKNNVYLYSLDWLSPPALPLVTDPLFR-----------------GCEHTWELQYIFSTSCNGFT 468

  Fly   469 LKREDPENFMIELLTRMWIEFAQKGDP 495
            ...:|  ..:....|..|:.|...|:|
 Worm   469 CTAQD--EILRNYFTTTWLNFIIGGNP 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	137/529 (26%)
cest-13	NP_741921.1	alpha/beta hydrolases	24..526	CDD:473884	137/524 (26%)