Protein Alignment CG4757 and cest-3

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_510042.2
• Gene: cest-3 / 181385
• WormBaseID: WBGene00008451
• Length: 588
• Species: Caenorhabditis elegans
• Alignment Length: 593
• Identity: 147/593 - (24%)
• Similarity: 227/593 - (38%)
• Gaps: 160/593 - (26%)

  Fly    23 VDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMCPQP 87
            :.|..|::.|    ..:.|:.|.|:.:.:|:||||.|||..|:...||. .|.:|:|..|.|...
 Worm    24 ISTTYGKLEG----KTVNVDQHMFKNVPFAKPPLGKLRFSLPEWTNPWK-NIRNATEYSPSCFSN 83

  Fly    88 WDNMTD-----VSEDCLRLNVYTKD--LKGRR-PVIVFLHPGGFYVFSG---QSKYLAGPEHFMD 141
            ....||     :|||||.|||:|.:  ||.:. ..:|:.|.||..:.|.   ...::.  |.::.
 Worm    84 SSMRTDSNFFPMSEDCLYLNVFTNEYCLKSKNCSTVVYYHGGGINMDSAVQFNDTFIL--ERYVK 146

  Fly   142 RDCVLVSLNYRLGSLGFLATGSKE-APGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGS 205
            .:.|.:...||||..|.|..||.. .|.|..:.|..||||:|.|.|..|||..|.:.|:|:|||:
 Worm   147 ENVVFIIPAYRLGIFGLLYFGSNNLVPQNLAIHDCELALRFIHQEISNFGGHKDDINLMGHSAGA 211

  Fly   206 ISVALHMLSPMSR------GLFHRGICMSAAP-YG-PVKYKDNDLQLAKRQAGLLKCPQESI--- 259
               .:.::...||      .|.:|.|.:|..| |. |.....|....|:|    :.|.:.::
 Worm   212 ---HISLIFGFSRHIDPDHKLINRIIVLSPVPSYDMPELLIKNCYDFAER----VGCYKRNVTAR 269

  Fly   260 -GEMVECMRRKPYLDYVSTYNGMFE---FGWNPVLNWRIVVEKDFGQERYLIESPFKTARRGDFH 320
             .|:|:|:|:|.....:|....|..   :.||
 Worm   270 DTEIVKCLRKKDARGLMSMQRLMENDRLYFWN--------------------------------- 301

  Fly   321 KVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREK-YMP 384
                        ||:|..|..|:|||.     |::.||....:|..|:.......|:.:|. .:.
 Worm   302 ------------FLAGEPFMYRDESIA-----DFKEYAVKRDMLIGNTVDEVKWKRLKKENPAIA 349

  Fly   385 ESLDKLEYPKSLKGMGELLSD-ALIGVSFHRFLQLMSPHTPIY----------TYLFRYKGRYTF 438
            .|....|.|..:........| |.:..::..|.|.:...|..|          .|||:
 Worm   350 GSFMDWENPYEVAHKFNFYHDSAPVNSTYESFTQGIFVSTATYAEAQANAGGTVYLFQ------- 407

  Fly   439 LKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKREDPENFMIELL----TRMWIEFAQKGDPH--- 496
                .|||   |..|...:..| ||     ..|||.....::::    ::|.:.|.:.|.|.
 Worm   408 ----SNQQ---PSSHVSDMQYF-VG-----THREDYHTSDMDIMDTFYSKMIVNFTKFGSPSPVW 459

  Fly   497 -----NKNDEYLKGLN-----WPL----YNAQDKGYLEIGNNLTA----------KSGGFFLNRY 537
                 ::.:.|...:|     ||.    ::..|..:..|  |:||          .|.|..|.
 Worm   460 EPLVPSRMNYYALEVNTEKGIWPRMEEDFHESDVNFWFI--NMTAFDREVTRQKKTSNGTSLT-- 520

  Fly   538 QIWEDLFP 545
              |..:.|
 Worm   521 --WSPMHP 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	145/586 (25%)
cest-3	NP_510042.2	alpha/beta hydrolases	21..496	CDD:473884	138/555 (25%)