DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and cest-9.1

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001359584.1	Gene:	cest-9.1 / 181383	WormBaseID:	WBGene00007692	Length:	614	Species:	Caenorhabditis elegans

Alignment Length:	597	Identity:	153/597 - (25%)
Similarity:	229/597 - (38%)	Gaps:	159/597 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LFVVELLVLLASSSVLSIEV-DTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPV 67
            :|:...|::|......|::| .|..|::||..:.|....:.:.|:.:.:|:||:|:|||..||..
Worm     1 MFIHLFLLILFIPQFQSLKVIQTSYGKLRGITVWSNDKNHRYMFKSVPFAKPPVGNLRFAKPQNP 65

  Fly    68 KPWSPKIFDASEDGPMC---------PQPWDNMTDVSEDCLRLNVYT--KDLKGRRPVIVFLHPG 121
            :.|| .|.|||:..|.|         ||     ...|||||.:|::|  |.|..:.||||:.|.|
Worm    66 ESWS-GILDASKYSPACMSNSSSTSTPQ-----KHYSEDCLYINIFTSEKCLNSKCPVIVYFHGG 124

  Fly   122 GFYVFSGQSKYLAGPEHFMDR----DCVLVSLNYRLGSLGFLATGSKE-APGNAGLKDQVLALRW 181
            .:.:   .|..:......:||    |.|.|....|||..|.|..|..: ...|..|.|.|.||.:
Worm   125 AYNL---DSAIMFNDTFILDRYAAEDVVFVIPAVRLGVFGQLYFGPSDLLSENLFLYDAVQALSF 186

  Fly   182 IQQHIQRFGGDPDSVTLLGYSAGSISV-ALHMLSPMSRG--LFHRGICMSAAP----YGPVKYKD 239
            :...|..||||...||.:|:|:|...| ||.....:..|  ||.:.|.:||..    |..|  .|
Worm   187 VHSEINYFGGDSKRVTAMGHSSGGTIVDALGFSKLIDPGVKLFQQMIVLSATGMFGFYDMV--VD 249

  Fly   240 NDLQLAKRQAGLLKC--------PQESIGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIVV 296
            |...:.::    ..|        |..:|.||::|||:....:.:.....|.|           |.
Worm   250 NSFAIVEK----FGCYNGTKDDRPNANIAEMLDCMRQIDGREMLLMQRHMEE-----------VD 299

  Fly   297 EKDFGQERYLIESPF--KTARRGDFHKVA----LITGITEFEF---------LSGAFFDLRNESI 346
            ::||  ...|..:||  ...:..|..|..    |:.|.||.||         :||.|.|..|...
Worm   300 DRDF--RSVLRGAPFLESNGKIADLKKSPPSRNLLYGTTEHEFRNVDHMNPYISGIFLDFDNPVA 362

  Fly   347 VNRYNRDWEHYASIALLLEQN--------STQSRAASRVFREKYMPESLDKLEYPKSLKGMGELL 403
            |.|| .|.:..|::..::..:        ||.|.|.:....:.|:.|:..|   |.|..     :
Worm   363 VARY-YDEQLMANLETMINGDAAAIFICASTFSTAMANTGADVYLFETRQK---PYSFH-----V 418

  Fly   404 SDALIGVSFHRFLQLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPL 468
            ||....|..||         .||                         |..::..|
Worm   419 SDMQYFVGIHR---------EIY-------------------------HRPDMDIL--------- 440

  Fly   469 LKREDPENFMIELLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSG--- 530
                  :.|..:||    :.|.:.|.|..:         |...:.:...|||:..:...|.|
Worm   441 ------DTFYSKLL----VNFTKMGVPSPE---------WAPLDPERMNYLELKVDSDMKEGPVM 486

  Fly   531 --GFFLNRYQIW 540
              ||.....::|
Worm   487 LEGFHEKEMELW 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	149/584 (26%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	62/179 (35%)
cest-9.1	NP_001359584.1	Abhydrolase	19..498	CDD:389770	148/577 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157187
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740