Protein Alignment CG4757 and cest-16

DIOPT Version :9

• Sequence 1: NP_001262469.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_741812.2
• Gene: cest-16 / 180905
• WormBaseID: WBGene00020330
• Length: 697
• Species: Caenorhabditis elegans
• Alignment Length: 651
• Identity: 165/651 - (25%)
• Similarity: 270/651 - (41%)
• Gaps: 157/651 - (24%)

  Fly     8 ELLVLL------ASSSVL--SIEVDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNP 64
            |||:||      |:..:|  |..|..|.|.||| |:.:..|.:...|||:.|||||:|:|||..|
 Worm     3 ELLLLLTFIFSWANGQLLEKSRSVWVEQGLVRG-NIYNIDGKHIQIFRGVPYAEPPIGELRFKPP 66

  Fly    65 QPVKPWSPKIFDASEDGPMCPQPWD----------NMTDVSEDCLRLNVY----TKDLKGRRPVI 115
            .....|..:: .|.|.||.|.|..|          ||...|||||.|||:    |.|.....|::
 Worm    67 VKKTRWHQEL-PAVEYGPPCLQFMDFHKNDKFAKTNMDRQSEDCLYLNVFSPYDTDDESKTYPIL 130

  Fly   116 VFLHPGGFYVFSGQS----KYLAGPEHFMDRDCVLVSLNYRLGSLGFL--ATGSKEAPGNAGLKD 174
            |::|.|.|...|..:    :.:|.  :.:.:....||:|||||.|||:  ..|.| ..||.|:.|
 Worm   131 VWIHGGSFLAGSADTGIDMEVIAA--NIVSKGIAFVSINYRLGPLGFMNYQNGDK-LEGNFGIWD 192

  Fly   175 QVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYG------ 233
            .|:||:|||.:|::|.|||..||::|.|||..:.:|..|||.:.||.|:.|.||.:...
 Worm   193 MVMALQWIQSNIKQFNGDPTKVTVMGESAGGAASSLLALSPKTSGLLHQAIIMSGSSMAGWAIHR 257

  Fly   234 ---PVKYKDN----------------------DLQ----------LAKRQAGLLKCPQESIGEM- 262
               |....||                      :.|          |...|...:.|..:.:.:|
 Worm   258 HSQPAYSVDNLVAYFRCEKWINEDDTKEVVGDEYQHLTHSVIRSALCNYQNVKINCLTDDMTQMD 322

  Fly   263 -VECMRRKPYLDYVSTYNGMF------EFGWNPVLNWRIVVEKDFGQERYLIESPFKTARRGDFH 320
             :.|:|::  |::.|.   :|      |.|.:     ::||:.|      |:.|...:..|.: .
 Worm   323 KMNCLRKE--LNFSSP---LFRKALAAELGVS-----KMVVDGD------LVPSSGVSLVRNN-A 370

  Fly   321 KVALITGIT--EFEFLSGAFFDLRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYM 383
            ::.::||:.  |:......|:::.....:.|.:.:.:.|..|.....:.:::..|.|.|   :.:
 Worm   371 RIPIMTGVARKEWGHKKAMFYNMHQRDGLKRSDVEEQVYRIIDNSFHETASEKLANSTV---QLI 432

  Fly   384 PES--LDKLEYPKSLKGMGELLSDALIGV--SFHRFLQLMSP-----------HTPIYTYLFRYK 433
            ..:  :..||.|.:     |.::|.::|.  .....::.::|           ..|:|.|.|.|.
 Worm   433 ANATIVRYLETPNN-----EFIADQVVGALQKLESDIEFVAPCEREVAAYVDKGVPVYLYSFDYV 492

  Fly   434 GRYTFL-----------------KNPDNQQTI--GPVHHDELIYLFHVGL-----LIPLLKREDP 474
            .:...|                 |..:..:.:  ...|..:..::|..|.     :.|..|||:.
 Worm   493 PKSPILESERKIYSLFGTKPVEMKRTEKSEILEKAAFHGLDHAFIFSKGYSSNFEISPYTKREET 557

  Fly   475 ENFMIELLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQI 539
               |.::|..|...|.:.|||....      .:||:::.....|:.:...|....|.......|.
 Worm   558 ---MSKILCTMLTNFVKNGDPSTTR------FSWPIFSGNSSQYVSLDVPLKLLEGEIHFPDAQF 613

  Fly   540 W 540
            |
 Worm   614 W 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	158/636 (25%)
		Aes	40..>204	CDD:223730	72/183 (39%)
cest-16	NP_741812.2	Abhydrolase	25..608	CDD:389770	155/621 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010