Protein Alignment CG4757 and cest-2.3

DIOPT Version :9

• Sequence 1: NP_001262469.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_506510.2
• Gene: cest-2.3 / 179918
• WormBaseID: WBGene00013873
• Length: 665
• Species: Caenorhabditis elegans
• Alignment Length: 615
• Identity: 148/615 - (24%)
• Similarity: 250/615 - (40%)
• Gaps: 130/615 - (21%)

  Fly     1 MLMLFVVELLVLLASSSVLSIEVDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQ 65
            :|......:|:.|:.|:.:.:...|..|::..|..:.........|.||.|.|||:|:|||..|:
 Worm     2 ILQYLYFAVLIHLSISTRIQLSTGTIEGKILNATYSPFGNQTATVFLGIPYVEPPIGELRFRKPR 66

  Fly    66 PVKPWSPKIFDASEDGPMCPQPWDN------MTDVSEDCLRLNVYTKD--LKGRR-PVIVFLHPG 121
            .:|.|. .:.:..:..|.|...|..      :.::|||||..||:|..  |:.:. .|::.:|.|
 Worm    67 LLKSWE-GVLETKDYKPACMSYWRKTFKNGFVGEISEDCLYANVFTNQYCLQNKNCSVMIVVHGG 130

  Fly   122 GFYVFSGQSKYLAGPEHFM------DRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALR 180
            .....||.:   ..||.|:      ||:.|:|:.|||||..||.....:....|..:.|.:.|::
 Worm   131 RLVCESGSA---FKPEIFINNFVGQDRNIVVVTFNYRLGVFGFGVFNGETGDTNVAMYDMLEAVK 192

  Fly   181 WIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDN----- 240
            |:::.|.:|||:.|.:|:.|:|||:..:.....|.:|:||.|:.|.|| ||...:....|
 Worm   193 WVRKEIDQFGGNKDRITMAGHSAGAGLIVDFTSSTLSKGLLHQQIVMS-APLQDISKSANFKGMT 256

  Fly   241 ----DLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYVST-----YNGMFEFG----------- 285
                ::....::.|..|..:..|.:...|::.|...|.:..     .|..|.||
 Worm   257 IVAQNVGCIPKEYGFRKLSKTQINKTYLCLQNKSAQDLLHAQLSMQQNSTFYFGSPRVDGDFITD 321

  Fly   286 -------WNPVLNWRIVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEF----------EF 333
                   :|.:......:....|:.|   :|.:.|..:.|..|..|:..:.|.          ||
 Worm   322 YPDNLFNFNTIYPINTFIGTTTGELR---DSLYITDPKNDRIKEQLLKNMCEHVGYELFEKPEEF 383

  Fly   334 LS--GAFFDLRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSL 396
            ..  |.::  :|.:.....:.|.|.|:.   .::..:...||.|:||...|        :|
 Worm   384 TKKCGNYY--KNGTDAQFLSDDMEFYSG---AIKVANAHKRANSKVFMYSY--------DY---- 431

  Fly   397 KGMGELLSDALIGVSFHRFLQLMSPHTP---IYTYLFRYKGRYTFLKNPDNQQTIGP-VHHDELI 457
            ||         .|.:||::|:..|||..   |||:                ..:.|| |..|.:|
 Worm   432 KG---------AGTAFHKYLEAPSPHHSEDLIYTF----------------GTSRGPFVAKDYVI 471

  Fly   458 YLFHVGLLIPLLKREDPENFMIELLTRMWIEFAQKGDPHNKNDEYLKGL--NWPLYNAQDKGY-- 518
            ...:.|:|...:..|||.    ...|:.|.::.|:     |.:.:|...  |:.:...:|..|
 Worm   472 ERIYSGMLANFINFEDPS----PSKTQQWRQYTQE-----KREYFLIDFDKNFTMPGMKDHYYTR 527

  Fly   519 -LEIGNNLTAKSGGFFLNRYQIWEDLFPLS 547
             |:..:....||   |..|:....|.|.:|
 Worm   528 ALDFWSTAGKKS---FSERFSPSLDNFVMS 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	142/592 (24%)
		Aes	40..>204	CDD:223730	57/178 (32%)
cest-2.3	NP_506510.2	Abhydrolase	20..532	CDD:389770	137/570 (24%)
		CemA	<550..>647	CDD:383495	2/5 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157031
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840