Protein Alignment CG4757 and cest-2.2

DIOPT Version :9

• Sequence 1: NP_001262469.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001256567.1
• Gene: cest-2.2 / 179917
• WormBaseID: WBGene00013874
• Length: 672
• Species: Caenorhabditis elegans
• Alignment Length: 587
• Identity: 142/587 - (24%)
• Similarity: 237/587 - (40%)
• Gaps: 130/587 - (22%)

  Fly     1 MLMLFVVELLVLLASSSVLSIEVDTELGRVRGANLT-------SRLGVNFHAFRGIRYAEPPLGD 58
            |...|.: |..:|.:.....:::.:..|.:.|..||       ::.|:   .|.|:.|.|||:|:
 Worm     1 MFFRFFI-LWAILQNVRSTKVKLSSRTGTIEGRTLTASYSPLGNQTGI---VFFGVPYVEPPVGN 61

  Fly    59 LRFVNPQPVKPWSPKIFDASEDGPMCPQPWDNMTD------------VSEDCLRLNVYTKD--LK 109
            |||..|:|.|||. .:.:|.|....|      |:|            ||||||..||:|..  |:
 Worm    62 LRFRKPRPPKPWD-GVLEAKEYKAAC------MSDQKKTYKNGVGGPVSEDCLYANVFTNQYCLE 119

  Fly   110 GRRPVIVFLHPGGFYVFSGQSKYLAGPEHFMD------RDCVLVSLNYRLGSLGFLATGSKEAPG 168
            .:...::....||.:|....|.|  .||..::      |:.|:|:.|||||..|...........
 Worm   120 HKNCSVMLTIHGGRFVIESASAY--DPEIIINNFVGQGRNIVVVTFNYRLGLFGLGMLNGDNQDT 182

  Fly   169 NAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYG 233
            |.||.|.:..:||.::.|:.||||.|.:|:.|:|||::..|....||:|:||.|:.|.|||: ..
 Worm   183 NFGLYDILEVVRWTRKEIKNFGGDKDRITMQGHSAGAVFTAAFSTSPLSKGLIHQQIIMSAS-MS 246

  Fly   234 PVKYKDN--DLQLAKRQAGLL-------KCPQESIGEMVECMRRKP---------YLDYVSTYNG 280
            .:..|.|  :|.:..|..|.|       |.....:.:...|:|.|.         |:...:||.
 Worm   247 NLSKKSNVKELTVVARIVGCLPDEHGFPKLSNVEVEKAYTCLRSKSAQQILDAQLYMLRNTTYY- 310

  Fly   281 MFEFGWNPVLNWRIVVEKDFGQER----YLIESPFKTARRGDFHKVALITGITEFEFLSGAFFDL 341
                               .||..    |.::.|.........:.:..:.|.|..|.:.
 Worm   311 -------------------IGQGHIDGIYQVDYPDNLYATNSIYPINTMIGTTTAELMD------ 350

  Fly   342 RNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDK-----LEYPKSLKGMGE 401
                  :||..|.::.....:|| ||..: .....:::|   ||...:     .:..:..|.:|:
 Worm   351 ------SRYIVDPKNTGKKEILL-QNLCE-HIGYELYKE---PEEFSQKCRNFYKNGEDAKSLGD 404

  Fly   402 LLSDALIGVSFHRFLQLMSPH----TPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHV 462
            .:.      .::..:||.:.|    |.::.|.|.||......|..|  :::.|.|.::..|.|..
 Worm   405 DME------FYYGAIQLANVHSSKDTNVFVYSFDYKEAGNAYKKYD--KSLSPKHGEDFAYAFGT 461

  Fly   463 GLLIPLLKREDPENFMIE-LLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGY--LEIGNN 524
            .     ......::::|| :.:.|:.:|...|||....|:     .|..|..:.:.|  ::...|
 Worm   462 N-----RGNFSTKDYVIEYIYSGMFADFVNFGDPSPLEDQ-----EWAQYTPEKREYFLIDFDKN 516

  Fly   525 LT 526
            .|
 Worm   517 FT 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	138/573 (24%)
		Aes	40..>204	CDD:223730	62/183 (34%)
cest-2.2	NP_001256567.1	Abhydrolase	25..534	CDD:389770	138/562 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157014
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940