Protein Alignment CG4757 and cest-2.1

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_506508.2
• Gene: cest-2.1 / 179916
• WormBaseID: WBGene00013875
• Length: 675
• Species: Caenorhabditis elegans
• Alignment Length: 589
• Identity: 149/589 - (25%)
• Similarity: 248/589 - (42%)
• Gaps: 105/589 - (17%)

  Fly     1 MLMLFVVELLVLLASSSVLSIEVDTELGRVRGANLTS-------RLGVNFHAFRGIRYAEPPLGD 58
            |::||:..|..||..|  :|..|....|.:.|..|||       ..|:   .|.||.:.|||.|:
 Worm     1 MVLLFLFLLSTLLHIS--ISTRVQLSTGTIEGKILTSTYSPLGNHTGI---GFLGIPFVEPPAGN 60

  Fly    59 LRFVNPQPVKPWSPKIFDASEDGPMCPQPWDNMTD------------VSEDCLRLNVYTKDLKGR 111
            |||..|:|..||. .|.:..|..|.|      |:|            :|||||..||:|.....:
 Worm    61 LRFRKPRPPIPWD-GILETKEYKPAC------MSDAKKTYKNGVGGPISEDCLYANVFTNQYCMK 118

  Fly   112 R---PVIVFLHPGGFYVFSGQSKYLAGPEHFMD------RDCVLVSLNYRLGSLGFLATGSKEAP 167
            |   .|::.:| ||..:....|.:  .||..::      |:.|:|:.|||||:.||.....::..
 Worm   119 RKNCSVMIVVH-GGRILTESASAF--NPEILVNNFVGQGRNIVVVTFNYRLGTFGFGVLNGEKGD 180

  Fly   168 GNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPY 232
            .|.|:.|.:.|::|.::.:..|||:.|.:|::|:|||...|.....||:|:|:.::.|.||.|.|
 Worm   181 SNVGMFDMLEAVKWTRKEVHNFGGNKDKLTMVGHSAGGSLVGAFTSSPLSKGMLNQQIIMSGALY 245

  Fly   233 GPVKYKD-NDLQLAKRQAGLL-------KCPQESIGEMVECMRRKPYLDYVSTYNGMFEFGWNPV 289
            ...|..: ..:....::||.|       |..|..|.:...|:|.      :|....:....|  |
 Worm   246 QMGKLANFKGMTAMAQKAGCLPEVFGFRKLSQVRIDKTYSCLRN------ISAQEVLDAQLW--V 302

  Fly   290 L---NWRIVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFEFLSGAFF-DLRNESIVNRY 350
            |   .:.|.|....|:  :|:....:....|..|.:..:.|.|..|.....:. ||:|.......
 Worm   303 LQNTTYYISVPHIDGE--FLLNYSDEILASGTIHPINSMIGTTTAELRDPIYINDLKNADKKEEL 365

  Fly   351 NRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESL-DKLE-YPKSLKGMGELLSDALIGVSFH 413
            .::...:....|..|.... ||...:.:......:.| |.:| |..|:|     :::|      |
 Worm   366 LKNLCEHIGYELYTEPEEF-SRKCQKFYGNGDDAQFLADDMEFYDGSIK-----VANA------H 418

  Fly   414 RFLQLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKRED--PEN 476
                 .|.:|.::.|.:.||......|.  ..|...|.|.::|||:|..       .|.:  .::
 Worm   419 -----ASKNTKVFMYSYDYKDAGPAFKK--YAQAPPPHHSEDLIYVFGT-------SRGNFTEKD 469

  Fly   477 FMIE-LLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGY--LEIGNNLT--AKSGGFFLNR 536
            ::|| :.:.|:.:|...|:|....::     .|..|:.:.:.|  ::...|.|  ....|::...
 Worm   470 YVIEQIYSGMFADFVNFGNPSPSKEQ-----KWKEYSPEKREYFLIDFDKNFTMPGTRDGYYSRA 529

  Fly   537 YQIW 540
            .:.|
 Worm   530 LEFW 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	141/568 (25%)
cest-2.1	NP_506508.2	COesterase	18..533	CDD:395084	141/568 (25%)