Protein Alignment CG4757 and cest-1.1

DIOPT Version :9

• Sequence 1: NP_001262469.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_506506.1
• Gene: cest-1.1 / 179915
• WormBaseID: WBGene00011362
• Length: 673
• Species: Caenorhabditis elegans
• Alignment Length: 594
• Identity: 148/594 - (24%)
• Similarity: 243/594 - (40%)
• Gaps: 133/594 - (22%)

  Fly    11 VLLASSSVLSIEVDTELGRVRGANLT---SRLGVNFHA--FRGIRYAEPPLGDLRFVNPQPVKPW 70
            |||.....:...|....|.:.|..|.   |.|| |..|  |.||.:.|||:||||:..|:|.|.|
 Worm     7 VLLLIQMYVCKRVQLSSGTIEGKILNISYSPLG-NQSATVFLGIPFVEPPIGDLRYRKPRPPKSW 70

  Fly    71 ----------------SPKIFDASEDGPMCPQPWDNMTDVSEDCLRLNVYTKD--LKGRRPVIVF 117
                            :.|.:.....||           :|||||.|||.|.:  |:.:...::.
 Worm    71 EGVLVTNEYKSACMSNATKTYKNKFGGP-----------ISEDCLYLNVLTNEYCLENKNCSVMM 124

  Fly   118 LHPGGFYVFSGQSKYLAGPEHFMD------RDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQV 176
            :..||.|:....|.:  .||..::      |:.|:|:.|||||...|..........|.||.|.:
 Worm   125 IVHGGGYLTESASTF--NPEILINNFVGQGRNIVVVTFNYRLGLFSFGQFNGDRGDKNFGLYDMI 187

  Fly   177 LALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDND 241
            .::.|:::.|:.|||:.:.:||.|:|||:..:.....||:::||.|:.|.|| ||...:..|.|.
 Worm   188 ESVNWVRREIENFGGNKNRITLAGHSAGASMIVAFTSSPLTKGLVHQQIIMS-APMTNMSKKSNF 251

  Fly   242 LQLAKRQAGLLKCPQESIG------EMVE----CMRRKPYLDYVST-----YNGMFEFGWNPVLN 291
            ..:.. .|.::.|..|.||      |.||    |:|:|.....:..     .|..:..|..|:
 Worm   252 KGMTV-MAQMVGCLSEEIGFNKLSEEQVENTYSCLRKKSAQQILDAQLWLLQNSTYFLGAPPI-- 313

  Fly   292 WRIVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFE------FLSGAFFDLRNESIVNRY 350
                      .|.:|.:.|.........:.:..:.|.|..|      .:..||.|.:.|.:.|.
 Worm   314 ----------DEHFLTDYPENLYASKSIYPINTLIGTTTLEVEESSYIIDPAFADKKVELLENL- 367

  Fly   351 NRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGVSFHRF 415
               .:|...:  |.|:..|.|:..    :::||..:..     .:|....|..:.|:.....|
 Worm   368 ---CDHIGYV--LYEEPETFSKKC----QKQYMNGNSS-----MNLSNEMEFYTPAIDFADSH-- 416

  Fly   416 LQLMSPHTPIYTYLFRYKG------RYTFLKNPDNQQTIGPVHHDE-LIYLF--HVGLLIPLLKR 471
               .|.:|.::.|.:.|:|      ||..:::|         ||.| |||:|  |.|:..
 Worm   417 ---TSGNTKVFLYSYDYRGAGPAYDRYLEVRSP---------HHSEDLIYVFGTHRGIFA----- 464

  Fly   472 EDPENFMIE-LLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLEIG---NNLT-AKSGG 531
              |::::|| :.:.|:.:|....:|....|:     .|..|..:::.:..|.   |.:| .....
 Worm   465 --PKDYIIEKIYSGMFADFVNFENPLPSGDQ-----KWNQYTKENREHFLINFDKNFITPGMRDN 522

  Fly   532 FFLNRYQIW 540
            ::...|:.|
 Worm   523 YYTEAYEFW 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	144/588 (24%)
		Aes	40..>204	CDD:223730	58/189 (31%)
cest-1.1	NP_506506.1	COesterase	19..531	CDD:278561	144/580 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157082
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840