Protein Alignment CG4757 and cest-1.2

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_506504.2
• Gene: cest-1.2 / 179914
• WormBaseID: WBGene00011364
• Length: 676
• Species: Caenorhabditis elegans
• Alignment Length: 590
• Identity: 158/590 - (26%)
• Similarity: 251/590 - (42%)
• Gaps: 106/590 - (17%)

  Fly     3 MLFVVELLVLLASSSVLSIEVDTELGRVRGANLTSRL----GVNFHAFRGIRYAEPPLGDLRFVN 63
            |:|...:|:..::...:|.:|....|.:.|..|.|..    ..:..||.||.|.|||:|||||..
 Worm     1 MIFKFVVLLWFSAQFAISTKVQLSTGIIEGKQLNSTYSPFGNQSAIAFLGIPYVEPPIGDLRFRK 65

  Fly    64 PQPVKPWSPKIFDASEDGPMCPQPWDNMT----------DVSEDCLRLNVYTKD--LKGRRPVIV 116
            |:|.|.|| .:.:..:..|.|   ..|.|          .:|||||.|||.|..  |:.:...:|
 Worm    66 PRPQKTWS-GVLETKKFKPAC---MSNSTKTYKNGGIGGPISEDCLYLNVLTNQYCLENKNCSVV 126

  Fly   117 FLHPGGFYVFSGQSKY----LAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVL 177
            .:..||.|:|...:.:    |.......||:.|:|::|||||..||......|...|.|:.|.:.
 Worm   127 IIVHGGGYLFESAATFNHEILVNNFVGQDRNIVVVTINYRLGIFGFGHLNGFEGDKNVGIFDTLE 191

  Fly   178 ALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDN-- 240
            |::|:::.|::|||:.|.:||.|:|||:..||...:||:::||.|:.|.|| .|...:..|.|
 Worm   192 AVKWVRREIKQFGGNKDRITLAGHSAGAGVVAAFTISPLTKGLIHQQIVMS-GPMTNMSKKSNFK 255

  Fly   241 -DLQLAKR------QAGLLKCPQESIGEMVECMRRKPYLDYVST-----YNGMFEFGWNPVLNWR 293
             ...:|:|      :.|..|.|:..:.::..|:|:||..:.:..     .|..|.||..||....
 Worm   256 GMTAMAERVGCHSKKYGFNKLPEHEVEQVYSCLRKKPAQELLDAQLWLLQNSTFYFGAPPVDGEF 320

  Fly   294 IVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYA 358
            |.   |:....|..:|.|         .:..:.|.|..|.....:....|      |::......
 Worm   321 IT---DYPDNLYSEKSIF---------SINTLLGTTTRELQDTGYISNSN------YSKFETKET 367

  Fly   359 SIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGVSFHRFLQLMSPHT 423
            .:..|.:|...:....|..|..|.....::..: .|||....|..:.|         :.|...|.
 Worm   368 FLKNLCDQIGIEIYKESEDFSSKCQKWYINGSD-SKSLSDDMEFYTQA---------INLADAHA 422

  Fly   424 ----PIYTYLFRYKG------RYTFLKNPDNQQTIGPVHHDE-LIYLF--HVGLLIPLLKREDPE 475
                .:|.|.:.|.|      :|..:|:|         ||.| |||.|  |.|:..       |:
 Worm   423 RKGKKVYMYSYAYSGAGPAFKKYMKVKSP---------HHSEDLIYTFGTHRGVFA-------PK 471

  Fly   476 NFMIE-LLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGY--LEIGNNLT--AKSGGFFLN 535
            :::|| :.:.|:.:|....||....|:     .|..|..::|.|  ::...|||  .....::..
 Worm   472 DYVIEYIYSGMFADFINFEDPSPSTDQ-----PWLQYTKENKEYFLVDFDQNLTMPGMKKNYYAK 531

  Fly   536 RYQIW 540
            .|:.|
 Worm   532 AYEFW 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	154/571 (27%)
cest-1.2	NP_506504.2	COesterase	18..536	CDD:395084	154/571 (27%)