Protein Alignment CG4757 and cest-35.2

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_504398.1
• Gene: cest-35.2 / 178910
• WormBaseID: WBGene00016863
• Length: 544
• Species: Caenorhabditis elegans
• Alignment Length: 585
• Identity: 167/585 - (28%)
• Similarity: 250/585 - (42%)
• Gaps: 120/585 - (20%)

  Fly    17 SVLSIEVDTEL-----GRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFD 76
            |.|..|.:||:     |.:|| |:........:.:.||.:|:.|:|||||......:.|:..: |
 Worm     6 SHLKPEKNTEVFNASCGPIRG-NVYEHGDKIVNGYLGIPFAKAPIGDLRFKKSVEAEKWTQPL-D 68

  Fly    77 ASEDGPMCPQ---------PWDNMTDVSED-CLRLNVYTKDLKGRR-----PVIVFLHPGGFYV- 125
            ..:.||.|||         ......|.:|| ||.|||:....|...     ||:|:.:.|||.|
 Worm    69 CYKYGPGCPQSAALGALMVSQATNHDFAEDNCLNLNVFAPKWKSAEFPNGFPVMVYFYGGGFEVG 133

  Fly   126 FSGQSKYLAGPEHFMD---------RDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRW 181
            ||..         |.|         :|.:||:.|||:|.|||.|||...|.||.||.||.|||:|
 Worm   134 FSSM---------FDDYSLTGTLPLKDVILVTPNYRIGPLGFFATGDDVARGNWGLWDQALALQW 189

  Fly   182 IQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAA---PYGPVKYKDNDLQ 243
            :|:||:.|||||.:||:.|.|||..||....|||.:...|.:.|.||.|   |:| ::.||.:..
 Worm   190 VQKHIKSFGGDPSNVTISGTSAGGASVDFLSLSPHANKYFQKFIPMSGAATCPFG-IRSKDVEGL 253

  Fly   244 LAKRQA---GLLKCPQESIGEMVECMRRKPYL---DYVSTYNGMFEFGWNPVLNWRIVVEKDFGQ 302
            :.:..|   |......:|:.:..:....:.:|   .|....:|||.|    |.|:    :.||
 Worm   254 IFREFANHHGYTGNDSKSLLQWYQSQDSEIFLKAEGYKCPASGMFSF----VPNF----DGDF-- 308

  Fly   303 ERYLIESPFKTARRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYA--------- 358
                ...||...|: :..|:..|..|.|:|   |..|:              :.||
 Worm   309 ----FPKPFDELRK-EAPKLGAIVSIGEYE---GLGFE--------------DFYAGQKTPQQML 351

  Fly   359 SIAL----LLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGV-SFHRFLQL 418
            |.||    :..:.....|||     |.|:....::.| ....|.:.|:..|....| :|.....|
 Worm   352 SAALGPEVVRNREEVVKRAA-----ESYLKNGGNENE-ENIAKTLVEIFGDYYFSVGAFDTVRSL 410

  Fly   419 MSPHTPIYTYLFRYKGRYT---FLKN-PDNQQTIGPVHHDELIYLFHVGLLIPLLKREDPENFMI 479
            :.....:|.|.|.|....|   |.|| |.|...    |..:|.|:|..|  .....:||.:  ::
 Worm   411 VKYGNTVYLYSFNYFNPNTPIVFGKNRPFNAAN----HGSDLRYIFGEG--TGEFSKEDRQ--VM 467

  Fly   480 ELLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKG-YLEIGNNLTAKSGGFFLNRYQIWEDL 543
            :::......||:.|:|:.|.    ..:.|..|:..:.| |.:|.......:..|...|::|.:::
 Worm   468 DMMGTYHTNFAKYGNPNGKG----VSVPWEKYSLDNPGRYFKIDYPKCEMADNFLDGRHKIIDEV 528

  Fly   544  543
             Worm   529  528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	164/577 (28%)
cest-35.2	NP_504398.1	COesterase	18..517	CDD:395084	159/560 (28%)