Protein Alignment CG4757 and cest-5.1

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_501022.3
• Gene: cest-5.1 / 177429
• WormBaseID: WBGene00015279
• Length: 580
• Species: Caenorhabditis elegans
• Alignment Length: 579
• Identity: 135/579 - (23%)
• Similarity: 231/579 - (39%)
• Gaps: 162/579 - (27%)

  Fly     1 MLMLFVVELLVLLASSSVLSIEVDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQ 65
            :|::|::.     |:.|::   :.|..|.:.||.:.     ::|.|:.|.:|:||:|:|||..|:
 Worm     7 LLLIFIIN-----AADSLI---IHTSFGHLEGAEIG-----DYHLFKKIPFAKPPVGNLRFQKPE 58

  Fly    66 PVKPWSPKIFDASEDGPMC---------PQPWDNMTDVSEDCLRLNVYT--KDLKGRR-PVIVFL 118
            ....|. .|..|.|.||.|         ||.|     |.||||.:|::|  |.||.|. .:.|::
 Worm    59 AAGKWD-GIRSAIEYGPACMSNSSKTKSPQKW-----VDEDCLHVNIFTSKKCLKSRNCAIAVYI 117

  Fly   119 HPGGF----YVFSGQSKYLAGPEHFMDRDCVLVSLNYRLGSLG-FLATGSKEAPGNAGLKDQVLA 178
            |.||.    .|....:..|   :.|:.||.:||...:|||... |.......||.|..|.|..||
 Worm   118 HGGGLTYDSAVMFNDTVLL---DTFVKRDVILVIPGFRLGIFSHFTVHNQNVAPNNLALYDITLA 179

  Fly   179 LRWIQQHIQRFGGDPDSVTLLGYS-AGSISVALHMLSPMSR--GLFHRGICMSAAPY-------- 232
            |.:::..|..|||:...:||.|:| .|.::..:...|.::|  .||.:.|.||...|
 Worm   180 LEFVKSEIHSFGGNSQKITLFGHSYGGGLASMMTFSSEINRDLSLFQQAIVMSGGFYFEELKDHI 244

  Fly   233 -------------GPVKYKDNDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYVSTYNGMFEF 284
                         .|:|. :..::.::::..::||.|:..|  :|.:|.:..|:    ..|..:|
 Worm   245 EGTKRFVEYANCSVPLKL-ERKMERSQQEMYMMKCLQKLSG--MELLRIQRLLE----DKGYPDF 302

  Fly   285 GWNPVLNWRIVVE-KDFGQERYLIESPFKTARRGDFHKVALITGITEFEF-------LSGAFFDL 341
            | ..:|...:..: |.|    .|::||         ..:.::||.|..||       ..|.:.:.
 Worm   303 G-GVILREPLFPDVKKF----ELLKSP---------KNIPMLTGCTNLEFDHESIKVPFGKYLEF 353

  Fly   342 RN-ESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLE---YPKSLKGMGEL 402
            .| :....:|..|.|           :..::|.           ...||.:   .|..|: :..|
 Worm   354 ENPDECDEKYRNDVE-----------SGVENRG-----------NHTDKTQGIILPLKLQ-INNL 395

  Fly   403 LSDALIGVSFHRFLQLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIP 467
            |.:.:...              :|.|.:...||:|                |:|.|:..|    .
 Worm   396 LENNVTAY--------------LYEYTYPKHGRHT----------------DDLSYIMGV----H 426

  Fly   468 LLKREDPENFMIELLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLEIGNNLT 526
            ..::::.|..:.::...|.|.|.:.|:|         |:.:......:..|.:|..|.|
 Worm   427 AFEKDENEVHLEQVYKDMVINFIKLGEP---------GMGFEKSEQNESTYFDIYWNET 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	131/560 (23%)
cest-5.1	NP_501022.3	alpha/beta hydrolases	17..495	CDD:473884	132/564 (23%)