DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4757 and cest-5.2

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_501021.3	Gene:	cest-5.2 / 177428	WormBaseID:	WBGene00015284	Length:	583	Species:	Caenorhabditis elegans

Alignment Length:	563	Identity:	145/563 - (25%)
Similarity:	232/563 - (41%)	Gaps:	140/563 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LVLLASSSVLSIEVDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKI 74
            |:|.:...|....:.|.|||:.|     :....:..||.|.:|:||:|.|||..|:..:.|: .:
Worm    11 LLLFSFQFVYPRIIKTSLGRLEG-----KQSGKYQLFRRIPFAKPPIGTLRFQKPESAEKWN-GV 69

  Fly    75 FDASEDGPMC---------PQPWDNMTDVSEDCLRLNVYTKD--LKGRR-PVIVFLHPGGFYVFS 127
            ::|:|.||.|         ||.|     |.||||.:|::|.|  ||.:. .|:|::| ||..||.
Worm    70 WNATEYGPACMSNSTWTQSPQKW-----VDEDCLHVNIFTSDKCLKSKDCAVVVYIH-GGEIVFD 128

  Fly   128 G----QSKYLAGPEHFMDRDCVLVSLNYRLGSLG-FLATGSKEAPGNAGLKDQVLALRWIQQHIQ 187
            .    ...:|.  |.|:.:|.:||...:|||... |.......||.|..|.|.:||..:::..|.
Worm   129 SAVMFNDTFLL--ESFVKQDVILVIPAFRLGIFSHFTVHDQNIAPNNLALYDIILAQEFVKSEIH 191

  Fly   188 RFGGDPDSVTLLGYS-AGSISVALHMLSPMSR--GLFHRGICMSAAPYGPVKYKDNDLQLAK--- 246
            .||||...:||.|:| .|:|:..:...|.:::  .||.|.|.|||..|    :...:.|:.:
Worm   192 NFGGDIQKITLFGHSYGGTIASMMAFSSEINQDLSLFQRIIVMSANQY----FDTLEEQIERSDR 252

  Fly   247 --RQAG------LLKCPQESIGE--MVECMRRKPYLDYVSTYNGMFEFGW----NPVLNWRIVVE 297
              :.||      |.:....|..|  |::|:::...::.:|....:.|.|:    |.||...:..:
Worm   253 VVKHAGCSVPTNLARKMNRSQKEKYMMKCLQKLSGMELLSVQRSLEEAGYPDIGNLVLRGPLFPD 317

  Fly   298 KDFGQERYLIESPFKTARRGDFHKVALITGITEFE--------FLSGAFFDLRNE-SIVNRYNRD 353
            .   ....::|||         ..:.::.|.|:||        |: |..|.|.|. ....:|.:|
Worm   318 V---TSLEMLESP---------KMIPMLAGCTKFESDDEDETHFI-GKHFGLENPIECDEKYRKD 369

  Fly   354 WEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGVSFHRFLQL 418
            .|:    .:...||.:....|..|               |..|                 |..||
Worm   370 LEN----GIFDRQNHSDKTQAIMV---------------PTKL-----------------RVDQL 398

  Fly   419 MSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKREDPENFMIELLT 483
            .....|.|.|.|.|. ::.|             |.|:|.|:..:.   |..|.|:.|: :.::..
Worm   399 RKHGVPAYLYEFTYP-KHAF-------------HTDDLYYIMGIH---PFEKDENEEH-LEKVYR 445

  Fly   484 RMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLEIGNNLT 526
            .|.|.|.:.|:|         |:.:.:.:..:..|.||..|.|
Worm   446 NMLINFIKFGEP---------GMGFEMSDLNESTYFEIYWNET 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	143/558 (26%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	63/181 (35%)
cest-5.2	NP_501021.3	Abhydrolase	23..498	CDD:389770	142/551 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156884
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740