Protein Alignment CG4757 and cest-5.2

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_501021.3
• Gene: cest-5.2 / 177428
• WormBaseID: WBGene00015284
• Length: 583
• Species: Caenorhabditis elegans
• Alignment Length: 563
• Identity: 145/563 - (25%)
• Similarity: 232/563 - (41%)
• Gaps: 140/563 - (24%)

  Fly    10 LVLLASSSVLSIEVDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKI 74
            |:|.:...|....:.|.|||:.|     :....:..||.|.:|:||:|.|||..|:..:.|: .:
 Worm    11 LLLFSFQFVYPRIIKTSLGRLEG-----KQSGKYQLFRRIPFAKPPIGTLRFQKPESAEKWN-GV 69

  Fly    75 FDASEDGPMC---------PQPWDNMTDVSEDCLRLNVYTKD--LKGRR-PVIVFLHPGGFYVFS 127
            ::|:|.||.|         ||.|     |.||||.:|::|.|  ||.:. .|:|::| ||..||.
 Worm    70 WNATEYGPACMSNSTWTQSPQKW-----VDEDCLHVNIFTSDKCLKSKDCAVVVYIH-GGEIVFD 128

  Fly   128 G----QSKYLAGPEHFMDRDCVLVSLNYRLGSLG-FLATGSKEAPGNAGLKDQVLALRWIQQHIQ 187
            .    ...:|.  |.|:.:|.:||...:|||... |.......||.|..|.|.:||..:::..|.
 Worm   129 SAVMFNDTFLL--ESFVKQDVILVIPAFRLGIFSHFTVHDQNIAPNNLALYDIILAQEFVKSEIH 191

  Fly   188 RFGGDPDSVTLLGYS-AGSISVALHMLSPMSR--GLFHRGICMSAAPYGPVKYKDNDLQLAK--- 246
            .||||...:||.|:| .|:|:..:...|.:::  .||.|.|.|||..|    :...:.|:.:
 Worm   192 NFGGDIQKITLFGHSYGGTIASMMAFSSEINQDLSLFQRIIVMSANQY----FDTLEEQIERSDR 252

  Fly   247 --RQAG------LLKCPQESIGE--MVECMRRKPYLDYVSTYNGMFEFGW----NPVLNWRIVVE 297
              :.||      |.:....|..|  |::|:::...::.:|....:.|.|:    |.||...:..:
 Worm   253 VVKHAGCSVPTNLARKMNRSQKEKYMMKCLQKLSGMELLSVQRSLEEAGYPDIGNLVLRGPLFPD 317

  Fly   298 KDFGQERYLIESPFKTARRGDFHKVALITGITEFE--------FLSGAFFDLRNE-SIVNRYNRD 353
            .   ....::|||         ..:.::.|.|:||        |: |..|.|.|. ....:|.:|
 Worm   318 V---TSLEMLESP---------KMIPMLAGCTKFESDDEDETHFI-GKHFGLENPIECDEKYRKD 369

  Fly   354 WEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGVSFHRFLQL 418
            .|:    .:...||.:....|..|               |..|                 |..||
 Worm   370 LEN----GIFDRQNHSDKTQAIMV---------------PTKL-----------------RVDQL 398

  Fly   419 MSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKREDPENFMIELLT 483
            .....|.|.|.|.|. ::.|             |.|:|.|:..:.   |..|.|:.|: :.::..
 Worm   399 RKHGVPAYLYEFTYP-KHAF-------------HTDDLYYIMGIH---PFEKDENEEH-LEKVYR 445

  Fly   484 RMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLEIGNNLT 526
            .|.|.|.:.|:|         |:.:.:.:..:..|.||..|.|
 Worm   446 NMLINFIKFGEP---------GMGFEMSDLNESTYFEIYWNET 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	142/553 (26%)
cest-5.2	NP_501021.3	alpha/beta hydrolases	21..498	CDD:473884	142/553 (26%)