Protein Alignment CG4757 and ace-4

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_496962.1
• Gene: ace-4 / 175074
• WormBaseID: WBGene00000038
• Length: 602
• Species: Caenorhabditis elegans
• Alignment Length: 639
• Identity: 173/639 - (27%)
• Similarity: 267/639 - (41%)
• Gaps: 143/639 - (22%)

  Fly     5 FVVELLVLLAS-SSVLSIEVDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVK 68
            |.:.:.|.:.| .:|..:.::|:||.::|..... |......|.|:.:|||.:.|.||..|:..|
 Worm    10 FFIFITVFIDSVQAVHPVVLETKLGDIKGTEFFF-LSKKIRTFFGVPFAEPAVEDFRFRKPREKK 73

  Fly    69 PWSPKIFDASEDGPMCPQP-------------WDNMTDVSEDCLRLNVYTKDLKGRRPVIVFLHP 120
            .|. .::||::....|.|.             |:..|.:|||||.||::.........|:|:...
 Worm    74 QWR-GLYDATKPANACFQTRDNYNTSFWGSEMWNANTQISEDCLYLNIWAPADAYNLTVMVWFFG 137

  Fly   121 GGFYVFSGQSKYLAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQH 185
            ||||..|.......|......::.::|::|||||..|||..|..:||||.||.||.|||.|::|:
 Worm   138 GGFYSGSPSLSIYDGKALTSTQNVIVVNINYRLGPFGFLYLGHPDAPGNMGLLDQQLALHWVRQN 202

  Fly   186 IQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSA------APYGPVKYKDNDLQL 244
            |..|||:||.|.:.|.|||:.|:..|:::|.|||||...|..|.      |...|.:.|    |.
 Worm   203 IVSFGGNPDKVAVFGQSAGAASIVAHLIAPGSRGLFKNAILQSGSLENTWAINSPFRAK----QK 263

  Fly   245 AKRQAGLLKCPQESIGEMVECMRR-KPYLDYVSTYNGMFEFGWNPVLNWR----IVVEKD---FG 301
            :::...|:.|.:.::...:.|:|. .|....:||        ||..|.:.    ::|.:|   ||
 Worm   264 SEKLLELVGCNKTTVDTSMACLRLVSPEQLSLST--------WNISLTYLEFPFVIVSRDKHFFG 320

  Fly   302 QERYLIESPFKTARRGDFHK-VALITGITEFE------FLSGAFFDLRNESIVNRYNRDWEHYAS 359
            .     .......|.|||:: |.|:.|:.:.|      :....|||..:...:||...|:
 Worm   321 H-----LDAHAALREGDFNRDVNLMIGMNKDEGNYWNIYQLPQFFDKADPPELNRTEFDF----- 375

  Fly   360 IALLLEQN-STQS---RAASRVFREKYM---PESLDKLEYPKSLKG-MGELLS------DALIGV 410
               |:::. |.|.   |:|:     ||:   |...|.....:...| |.:::.      |:|...
 Worm   376 ---LIDRTFSIQPDIIRSAA-----KYIYSDPNCTDHGRKTRFYAGQMNQIVGDYFFSCDSLWLA 432

  Fly   411 SFHRFLQLMSPHTP------IYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPL- 468
            ...|.:..:...:|      ::.|.|.....    .||..:.| |.:|..|:.|:|.    |||
 Worm   433 DQFRSIPRVKSSSPQRKPGKVFVYHFTQSSS----ANPWPKWT-GAMHGYEIEYVFG----IPLS 488

  Fly   469 ----LKREDPENFMIELLTRMWIEFAQKGDPH---NKNDEYLKGLNWPLYNAQDKGY----LEIG 522
                .||.  |......:.:.|..||:.|.|.   .||.|:     ||.:|.|:. |    |..|
 Worm   489 YSKNYKRR--EQIFSRKIMQFWASFAKNGTPKLRVLKNSEH-----WPEFNEQNH-YRWMQLRSG 545

  Fly   523 NN--------------------------LTAKSGGFFLNRYQIWEDLF-PLSSF 549
            :|                          ||.:.....|..|..|..|: ||..|
 Worm   546 SNIRPIKPKKQVECQFWRRVKDTEYTAYLTQEYSSSSLTTYSYWLLLYIPLFIF 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	164/611 (27%)
ace-4	NP_496962.1	COesterase	28..562	CDD:395084	160/582 (27%)