DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and cest-27

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_871861.2	Gene:	cest-27 / 171610	WormBaseID:	WBGene00018958	Length:	561	Species:	Caenorhabditis elegans

Alignment Length:	535	Identity:	152/535 - (28%)
Similarity:	233/535 - (43%)	Gaps:	109/535 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMCPQ-- 86
            |...|.::|.......|.....|.||.|||||:|.|||..|...:.|:..: |....||..||
Worm    29 DATCGPIKGVGYEQEDGSVVEGFLGIPYAEPPIGALRFKKPVAHRKWTEPL-DCVRFGPRSPQND 92

  Fly    87 ----PWDNMTDVSED-CLRLNVYTKDLKGRR-----PVIVFLHPGGFYVFSGQSKYLAG-PEHFM 140
                .:.|....||: ||.|||:|...:...     ||:||:|.|||.|.|..:...|. ..:..
Worm    93 ELLGQFVNTVGKSEEHCLSLNVFTPKWESNEWPDGFPVMVFIHGGGFAVHSSSNYGCASIARNLC 157

  Fly   141 DRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGS 205
            .:|.|:|::|||||.|||..||.:...||.||.||..||.|:|::||.|.||||:||:.|.|||.
Worm   158 TKDVVVVTINYRLGVLGFFTTGDEVCRGNLGLWDQTAALEWVQENIQSFRGDPDNVTIFGQSAGG 222

  Fly   206 ISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAKRQAGLLKCPQESIG---------E 261
            .||.|..|||.|||||:|.|.|  |..|..   |..::.:::||.|.:.....:|         :
Worm   223 ASVDLLCLSPHSRGLFNRAIPM--AGNGEC---DFAMRTSEQQAQLSREFARYLGWEGDDNDSED 282

  Fly   262 MVECMRRKPYLDYVSTYNGMFEFGWNP--------------VLNWRIVVEKDFGQERYLIESPFK 312
            :::      ::|....|.  .|.|.||              |.|:    :.||      ...|..
Worm   283 LLQ------FIDQQPLYK--IEMGINPKRGFKHSQAGSLYFVPNF----DGDF------FPKPLN 329

  Fly   313 TARRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRV 377
            ..|: :..|:.::||.|::|   |.||                  .::..|.:......:...|:
Worm   330 QLRK-EAPKMQIMTGTTKYE---GLFF------------------IALGALSKNPEGIKKFMGRI 372

  Fly   378 FREKYMPESLDKL---------------EYPKSLKGMGELLSDALIGVSFHRFLQLMSP-HTPIY 426
            |:|....|..|.:               ::.|::..:.:.:.|..|....:|...:|:. ...:|
Worm   373 FKECDYGERADDVLQMVYDFYFKGVHPKDHEKNMHQIVKFIGDYSINYGTYRLANIMTDLQHDVY 437

  Fly   427 TYLFRYK-----GRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKREDPENFMIELLTRMW 486
            .|.|.|.     |.:.:|     ...:|..|..|:.|:...| :|...:..|.:..|:.::|..:
Worm   438 FYQFDYHNSAGFGVFRWL-----LPFLGSTHCTEMRYVLGKG-IISKFRPNDNDKKMLHVMTTYF 496

  Fly   487 IEFAQKGDPHNKNDE 501
            ..||:.|:|:.:|.|
Worm   497 TNFAKYGNPNGENQE 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	152/535 (28%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	74/176 (42%)
cest-27	NP_871861.2	COesterase	29..541	CDD:278561	152/535 (28%)
cest-27	NP_871861.2	Aes	<114..>283	CDD:223730	70/173 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157296
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850