DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and Ces2c

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_598270.2	Gene:	Ces2c / 171118	RGDID:	621510	Length:	561	Species:	Rattus norvegicus

Alignment Length:	584	Identity:	167/584 - (28%)
Similarity:	263/584 - (45%)	Gaps:	103/584 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLVLL--------ASSSVLSIEVDTELGRVRGA---NLTSRLGVNFHAFRGIRYAEPPLGDLRFV 62
            ||:|:        .|||:.:    |..|:|||.   ...::.||  |.|.||.:|:.|:|.|||.
  Rat    18 LLILIHVWGQDSPESSSIRT----THTGQVRGKLDHVRDTKAGV--HTFLGIPFAKAPVGPLRFA 76

  Fly    63 NPQPVKPWSPKIFDASEDGPMCPQPWDNMTDV--------------SEDCLRLNVYT-------K 106
            .|:..:||| .:.|.:....||.|..|.:.:|              |||||.||:||       .
  Rat    77 PPEDPEPWS-GVRDGTSHPAMCLQNIDMLDEVGLTDMKMILSSIPMSEDCLYLNIYTPAHAHEGS 140

  Fly   107 DLKGRRPVIVFLHPGGFYVFSGQSKYLAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAG 171
            :|    ||:|.:|.|...:  |.:....|....::.|.|:|::.||||.|||.:||.:.|.||.|
  Rat   141 NL----PVMVCIHGGALVI--GMASMCDGSLLAVNEDLVVVAIQYRLGVLGFFSTGDEHARGNWG 199

  Fly   172 LKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVK 236
            ..|||.||||:||:|..|||:|:.||:.|.|||..||:.|::||||:||||..|..|.....|..
  Rat   200 YLDQVAALRWVQQNIAHFGGNPNRVTIFGVSAGGTSVSSHVISPMSQGLFHGAIMESGVALLPDL 264

  Fly   237 YKDNDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIVVEKDFG 301
            ..:....::...|.|..|.......:|.|:|.|...: :...|.:|:.  .|.     ||:.:|
  Rat   265 ISETSETVSTTVAKLSGCEATDSETLVRCLRAKSGAE-ILVINKVFKM--IPA-----VVDGEF- 320

  Fly   302 QERYLIESPFKTARRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYASIALLLEQ 366
                |...|.:.....|||.|..|.|:...|:.......:....|:...:|:     ::..:|:.
  Rat   321 ----LPRHPKELLASEDFHPVPSIIGVNTDEYCCTIPMVMGTAQIIKELSRE-----NLQAVLKD 376

  Fly   367 NSTQSR---AASRVFREKYM-----PESLDKLEYPKSLKGMGELLSDALIGVSFHRFLQLMSPHT 423
            .:.|..   ....:..|:||     |::| :::|       .|::.|.|..:...:.......|.
  Rat   377 TAAQMMLPPECGDLLMEEYMGNTDDPQTL-QIQY-------AEMMGDFLFVIPALQVAHFQRSHA 433

  Fly   424 PIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYL---FHVGLLIPLLKREDPENFMIELLTR- 484
            |:|.|.|::...|.....|.:   :...|.||:.::   |..|:.:...:.|       :||:|
  Rat   434 PVYFYEFQHAPSYFKNVRPPH---VKADHADEVPFVFGSFFWGIKVDFTEEE-------KLLSRR 488

  Fly   485 ---MWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQIWEDLFP 545
               .|..||:.|:|:::...|     ||:.: .|:.||:: :...|........|.|.|....|
  Rat   489 MMKYWANFARHGNPNSEGLPY-----WPVLD-HDEQYLQL-DTQPAVDRALKARRLQFWTKTLP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	162/563 (29%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	73/184 (40%)
Ces2c	NP_598270.2	COesterase	32..540	CDD:395084	162/563 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.970