Protein Alignment CG4757 and Ces3b

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_653094.2
• Gene: Ces3b / 13909
• MGIID: 3644960
• Length: 571
• Species: Mus musculus
• Alignment Length: 602
• Identity: 181/602 - (30%)
• Similarity: 266/602 - (44%)
• Gaps: 115/602 - (19%)

  Fly     1 MLMLFVVELLVLLASSSVLSIEVDTELGRVRGANL----TSRLGVNFHAFRGIRYAEPPLGDLRF 61
            :|:.||    ..:....|:..||||.||||||..:    |.|: ||  .|.||.:|:.|:|.|||
Mouse    21 LLLAFV----TTVTGPKVIQPEVDTPLGRVRGRQVGVKDTDRM-VN--VFLGIPFAQAPVGPLRF 78

  Fly    62 VNPQPVKPWSPKIFDASEDGPMCPQPWDNMTD-------------VSEDCLRLNVY--TKDLKG- 110
            ..|.|.:||. .:.|||.:.|||.|..:.|.:             :|||||.||:|  |:...|
Mouse    79 SAPLPPQPWE-GVRDASINPPMCLQDVEKMINSRFGLNEKIKIFPISEDCLTLNIYSPTEITAGD 142

  Fly   111 RRPVIVFLHPGGFYVFSGQSKYLAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQ 175
            :|||:|::|.|...|  |.|....|.......|.|:|::.||||..|||:||.|..|||.|..|.
Mouse   143 KRPVMVWIHGGSLLV--GSSTSQDGSALAAYGDVVVVTVQYRLGIFGFLSTGDKHMPGNRGFLDV 205

  Fly   176 VLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDN 240
            |.||||:|.:|..|||||:.||:.|.|||.:.|:...|||:|.|||||.|..|......:.....
Mouse   206 VAALRWVQGNIAPFGGDPNCVTIFGNSAGGMIVSSLFLSPISAGLFHRAISQSGIVTTIMMEDMK 270

  Fly   241 DLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIVVEKDFGQERY 305
            ....|:..|..:.|...|..|:|:|:.:|...|.:...|          :|...:|...|..:|
Mouse   271 PWPEAQNFANSVACGSASPAELVQCLLQKEGKDLIKQKN----------VNISYIVNDSFFPQR- 324

  Fly   306 LIESPFKTARRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYASIALLLEQNSTQ 370
                |.|......|..|..:.|:|..||   .:..|::.:|:::.    ||.:...||
Mouse   325 ----PEKLLADQQFPTVPYLLGVTNHEF---GWLLLKSLNILDKL----EHLSREDLL------- 371

  Fly   371 SRAASRVF------REKYMPESLDKL-----EYPKSLKGMGELLSD---ALIGVSFHRFLQLMSP 421
              ..||.|      ..:.||..:|:.     :...:.....|||.|   .:..::|.::|:  ..
Mouse   372 --EISRPFLAIMEVPPEIMPTVIDEYLDNGSDQSATRYAFQELLGDISFIIPTLNFSKYLR--DA 432

  Fly   422 HTPIYTYLFRYKGRYTFLKNPDNQQTIGPV-----HHDELIYLF------HVGLLIPLLKREDPE 475
            ..|::.|.|::        .|.:.....|.     |..|..::|      ....|:...:..:.|
Mouse   433 GCPVFLYEFQH--------TPSSFAKFKPAWVKADHASENSFVFGGPFLTDESSLLAFPEATEEE 489

  Fly   476 NFMIELLTRMWIEFAQKGDPHNKNDEYLKGL-NWPLYNAQDKGYLEIG----NNLTAKSGGFFLN 535
            ..:...:...|.:||:.|:|:.      ||| .||..| |.:.|||||    ..:..|.|
Mouse   490 KQLSLTMMAQWSQFARTGNPNG------KGLPPWPQLN-QLEQYLEIGLESRTGVKLKKG----- 542

  Fly   536 RYQIWEDLFP--LSSFH 550
            |.|.|.:..|  :..:|
Mouse   543 RLQFWTETLPRKIQEWH 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	174/569 (31%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:395084	174/569 (31%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571