DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4757 and Ces1c

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_031980.2	Gene:	Ces1c / 13884	MGIID:	95420	Length:	554	Species:	Mus musculus

Alignment Length:	578	Identity:	179/578 - (30%)
Similarity:	263/578 - (45%)	Gaps:	111/578 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SVLSIEVDTELGRVRGANLTSRLGVNFH----AFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDA 77
            |:|...|||..|:|.|..::..   .|.    .|.|:.:|:||||.|||..|||.:||| .:.:|
Mouse    20 SLLPPVVDTTQGKVLGKYISLE---GFEQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWS-FVKNA 80

  Fly    78 SEDGPMCPQP--WDNMTD-------------VSEDCLRLNVYT-KDL--KGRRPVIVFLHPGGFY 124
            :...|||.|.  |..:..             :|||||.||:|: .||  ..:.||:|::|.||.
Mouse    81 TSYPPMCSQDAGWAKILSDMFSTEKEILPLKISEDCLYLNIYSPADLTKSSQLPVMVWIHGGGL- 144

  Fly   125 VFSGQSKY--LAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQ 187
            |..|.|.|  ||...|   .:.|:|::.||||..|..:||.:.:|||....||:.||||:|.:|.
Mouse   145 VIGGASPYNGLALSAH---ENVVVVTIQYRLGIWGLFSTGDEHSPGNWAHLDQLAALRWVQDNIA 206

  Fly   188 RFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAKRQAGLL 252
            .|||:|||||:.|.|:|.|||::.:|||:.:.||||.|..|.........|.|...:.:..|.|.
Mouse   207 NFGGNPDSVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGVVINTNVGKKNIQAVNEIIATLS 271

  Fly   253 KCPQESIGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRI---VVEKDFGQERYLIESPFKTA 314
            :|...|...||:|:|:|...:.:.....:.::  |..|:..|   |:.|  ..|..|.|..|.|
Mouse   272 QCNDTSSAAMVQCLRQKTESELLEISGKLVQY--NISLSTMIDGVVLPK--APEEILAEKSFNT- 331

  Fly   315 RRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFR 379
                   |..|.|..:.||                   .|.....:..||.:.......||.:.|
Mouse   332 -------VPYIVGFNKQEF-------------------GWIIPMMLQNLLPEGKMNEETASLLLR 370

  Fly   380 ----EKYMPESLDKLEYPKSLKGM------GELLSDALIGVSFHRFLQLMS-----PHTPIYTYL 429
                |..:.||:......:.|:|:      .||:.|....:.|.....|:|     .....|.|.
Mouse   371 RFHSELNISESMIPAVIEQYLRGVDDPAKKSELILDMFGDIFFGIPAVLLSRSLRDAGVSTYMYE 435

  Fly   430 FRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKR--EDPENFMIELLTRMWIEFAQK 492
            |||:..:...|.|   ||:...|.||:.::|..    ||||.  .:.|..:.:::.:.|..||:.
Mouse   436 FRYRPSFVSDKRP---QTVEGDHGDEIFFVFGA----PLLKEGASEEETNLSKMVMKFWANFARN 493

  Fly   493 GDPHNKNDEYLKGL-NWPLYNAQDKGYLEIG------NNLTAKSGGFFLNRYQIWEDL 543
            |:|:.      :|| :||.|:.|: |||:||      ..|.|:...|       |.:|
Mouse   494 GNPNG------EGLPHWPEYDEQE-GYLQIGATTQQAQRLKAEEVAF-------WTEL 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	177/573 (31%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	76/187 (41%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	172/552 (31%)
		Aes	<121..>234	CDD:223730	51/116 (44%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832561
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3450
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.900