Protein Alignment CG4757 and AADAC

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001077.2
• Gene: AADAC / 13
• HGNCID: 17
• Length: 399
• Species: Homo sapiens
• Alignment Length: 404
• Identity: 80/404 - (19%)
• Similarity: 144/404 - (35%)
• Gaps: 121/404 - (29%)

  Fly    73 KIFDASEDGPMCPQPWDNMTDVSE---DCLRLNVYTKDLKGR--RPVIVFLHPGGFYVFSGQ--- 129
            |:..:.::.|  |...:|:| |:|   :.:.:.||....|..  |..:.::|.||:.|.|..
Human    63 KVVGSFDEVP--PTSDENVT-VTETKFNNILVRVYVPKRKSEALRRGLFYIHGGGWCVGSAALSG 124

  Fly   130 ----SKYLAGPEHFMDR-DCVLVSLNYRLGSLGFLATGSKEAPG---NAGLKDQVLALRWI--QQ 184
                |::.|      || |.|:||.||||            ||.   ....:|...||||.  ::
Human   125 YDLLSRWTA------DRLDAVVVSTNYRL------------APKYHFPIQFEDVYNALRWFLRKK 171

  Fly   185 HIQRFGGDPDSVTLLGYSAG---------------SISVALHM-------LSPMSRGLFHRGICM 227
            .:.::|.:|:.:.:.|.|||               .:.:.|.:       |.|:...|
Human   172 VLAKYGVNPERIGISGDSAGGNLAAAVTQQLLDDPDVKIKLKIQSLIYPALQPLDVDL------- 229

  Fly   228 SAAPYGPVKYKDNDLQLAKRQAGLLKCPQE---SIGEMVECMRRKPYLDYVSTYNGMFEF-GWNP 288
                   ..|::|...|...::.:::...|   :...:.:.|..:.::...|::  :|:| .|:.
Human   230 -------PSYQENSNFLFLSKSLMVRFWSEYFTTDRSLEKAMLSRQHVPVESSH--LFKFVNWSS 285

  Fly   289 VLNWRIVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRD 353
            :|..|.:....:....|                     |.:|.......|.|:|
Human   286 LLPERFIKGHVYNNPNY---------------------GSSELAKKYPGFLDVR----------- 318

  Fly   354 WEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGVSFH---RF 415
                 :..||.:.|..:....:.|...:|.....|.|.|...|:..|..::...:...||   .|
Human   319 -----AAPLLADDNKLRGLPLTYVITCQYDLLRDDGLMYVTRLRNTGVQVTHNHVEDGFHGAFSF 378

  Fly   416 LQLMSPHTPIYTYL 429
            |.|...|..|..|:
Human   379 LGLKISHRLINQYI 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	80/404 (20%)
AADAC	NP_001077.2	Abhydrolase_3	107..374	CDD:400284	62/337 (18%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	111..113		1/1 (100%)