Protein Alignment CG4757 and Nlgn1

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: XP_038957495.1
• Gene: Nlgn1 / 116647
• RGDID: 621117
• Length: 863
• Species: Rattus norvegicus
• Alignment Length: 703
• Identity: 168/703 - (23%)
• Similarity: 261/703 - (37%)
• Gaps: 257/703 - (36%)

  Fly    12 LLASSSVLSIEVD-------TELGRVRG--ANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPV 67
            ||.:..|||.::|       |..|::||  ..|.:.:......|.|:.||.||.|:.||..|:|.
  Rat    37 LLQTFHVLSQKLDDVDPLVTTNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPP 101

  Fly    68 KPWSPKIFDASEDGPMCPQ-------------PW--DNM-------TDVSEDCLRLNVY--TKDL 108
            .||| .|.:|::..|:|||             .|  :|:       .|.|||||.||:|  |:|:
  Rat   102 SPWS-DIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDV 165

  Fly   109 K--------------------------------------------GRRPVIVFLHPGGFYVFSGQ 129
            |                                            |.:||:|::|.|
  Rat   166 KRISKECARKPGKKICRKGGPLTKTQTDDLGDNDRAEDEDIRDSGGPKPVMVYIHGG-------- 222

  Fly   130 SKYLAGPEHFMD-------RDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQ 187
             .|:.|..:..|       .:.:::::|||||.||||:||.:.|.||.||.|.:.||||..::|.
  Rat   223 -SYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIG 286

  Fly   188 RFGGDPDSVTLLGYSAGSISVALHMLSPMS---------RGLFHRGICMS-------AAPYGPVK 236
            .|||||..:|:.|..||...|.|..||..|         :|||.|.|..|       |..:.|.|
  Rat   287 FFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAK 351

  Fly   237 YKDNDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYV--STYNGMFEFGWNPVLNWRIVVEKD 299
            |       |:..|..:.|......|:|||:::|||.:.|  ......:...:.||::..::.:
  Rat   352 Y-------ARILATKVGCNVSDTVELVECLQKKPYKELVDQDVQPARYHIAFGPVIDGDVIPD-- 407

  Fly   300 FGQERYLIESPFKTARRGDFHKVALITGI---------------------TEFEFLSGAFF---- 339
              ..:.|:|       :|:|....::.|:                     ::|:|....|.
  Rat   408 --DPQILME-------QGEFLNYDIMLGVNQGEGLKFVENIVDSDDGVSASDFDFAVSNFVDNLY 463

  Fly   340 ------DLRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKG 398
                  |:..|:|...|. ||                        .:::.||:..|
  Rat   464 GYPEGKDVLRETIKFMYT-DW------------------------ADRHNPETRRK--------- 494

  Fly   399 MGELLSDALIGVSFHRFLQLMSPH-----------------TPIYTYLFRYKGRYTFLKNPDNQQ 446
                           ..|.|.:.|                 :|.|.|.|     |...:......
  Rat   495 ---------------TLLALFTDHQWVAPAVATADLHSNFGSPTYFYAF-----YHHCQTDQVPA 539

  Fly   447 TIGPVHHDELIYLFHVGLLIPLLKRED--PENF------MIELLTRMWIEFAQKGDP-------- 495
            .....|.||:.|:    |.||::...:  |.||      :..::...|..||:.|||
  Rat   540 WADAAHGDEVPYV----LGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDT 600

  Fly   496 ---HNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQIWEDLFP 545
               |.|.:.: :.:.|..|:.:|:.||.||.....|. .:..|:..:|.:|.|
  Rat   601 KFIHTKPNRF-EEVAWTRYSQKDQLYLHIGLKPRVKE-HYRANKVNLWLELVP 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	161/688 (23%)
Nlgn1	XP_038957495.1	COesterase	52..646	CDD:395084	159/681 (23%)