Protein Alignment CG4757 and ache

DIOPT Version :9

• Sequence 1: NP_001262469.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_571921.1
• Gene: ache / 114549
• ZFINID: ZDB-GENE-010906-1
• Length: 634
• Species: Danio rerio
• Alignment Length: 625
• Identity: 177/625 - (28%)
• Similarity: 276/625 - (44%)
• Gaps: 123/625 - (19%)

  Fly     2 LMLFVVELLVLLASSSVLSIEVD----TELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFV 62
            ::|....||..|..:.....|.|    |.||||:|..|......:..||.||.|||||:|..||.
Zfish     6 ILLLPTVLLTFLFHNCFAQAEPDLVVATRLGRVQGTRLPVPDRSHVIAFLGIPYAEPPIGKRRFK 70

  Fly    63 NPQPVKPWSPKIFDASEDGPMCPQ-------------PWDNMTDVSEDCLRLNVYTKDLKGRRP- 113
            ..:|.|||: .:|:|.|....|.|             .|:....:|||||.|||:.....  ||
Zfish    71 RAEPKKPWN-NVFEAKEFSNACYQFVDTSYPGFPGIEMWNPNRVMSEDCLYLNVWVPPTP--RPQ 132

  Fly   114 ---VIVFLHPGGFYVFSGQS-------KYLAGPEHFMDRDCVLVSLNYRLGSLGFLA-TGSKEAP 167
               |:|:::.||||  ||.|       :|||..|     ..|:||:|||:|:.|||| .||.:||
Zfish   133 NLTVMVWIYGGGFY--SGSSSLDVYDGRYLAYTE-----KVVVVSMNYRVGAFGFLALNGSSDAP 190

  Fly   168 GNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPY 232
            ||.||.||.|||:|:|::|..|||:|..||:.|.|||:.||.:|:|||.||.||.|.|..|..|.
Zfish   191 GNVGLYDQRLALQWVQENIHFFGGNPKQVTIFGESAGAASVGMHVLSPDSRPLFTRAILQSGVPN 255

  Fly   233 GP---VKYKDNDLQLAKRQAGLLKCPQESIGEMVECMRRK---PYLD---YVSTYNGMFEFGWNP 288
            .|   |.: |...:...:...|:.|...:..|:::|:|.|   ..:|   .|..::.:|.|.:.|
Zfish   256 TPWATVTF-DEARRRTTKLGKLVGCTWGNDTELIDCLRNKHPQELIDQEWQVLPWSSLFRFSFVP 319

  Fly   289 VLNWRIVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFE----FLSGA-FFDLRNESIVN 348
            |::           ..:..::|......|:|....::.|:.:.|    .|.|| .|...|||:::
Zfish   320 VVD-----------GVFFPDTPDAMISSGNFKYTQILLGVNQDEGSYFLLYGAPGFSKDNESLIS 373

  Fly   349 RYNRDWEHYASIALLLEQNSTQSRAASRVFREKYM---PESLDKLEYPKSLKGMGELLSDALI-- 408
            |.:           .||........|:.:..|..:   .:.:|:....|:...|.:::.|..:
Zfish   374 RED-----------FLESVKMGVPHANDIGLEAVILQYTDWMDENNGQKNRDAMDDIVGDQNVIC 427

  Fly   409 -----GVSFHRFLQLM------------------------SPHTPIYTYLFRYKGRYTFLKNPDN 444
                 ..|:.::..|.                        :.|..:|.|||.::.     .|...
Zfish   428 PLQHFAKSYAQYAALHAQSSAAAPGTLGWGNSGPTGYNSGNSHGAVYLYLFDHRA-----SNLAW 487

  Fly   445 QQTIGPVHHDELIYLFHVGLLIPLLKRED---PENFMIELLTRMWIEFAQKGDPHNKNDEYLKG- 505
            .:.:|.:|..|:.::|  ||  ||.||.:   .|..:...:.|.|..||:.|:|:...|..:..
Zfish   488 PEWMGVIHGYEIEFVF--GL--PLEKRLNYTAEEEKLSRRIMRYWANFARTGNPNVNTDGTMDSR 548

  Fly   506 LNWPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQIWEDLFP 545
            ..||.::|.::.::.:.........|.......:|....|
Zfish   549 RRWPQFSANEQKHVGLNTEPMKVHKGLRTQFCALWNRFLP 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	171/605 (28%)
		Aes	40..>204	CDD:223730	80/188 (43%)
ache	NP_571921.1	COesterase	23..583	CDD:278561	171/601 (28%)
		AChE_tetra	598..631	CDD:285837

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575596
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840