DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and Ache

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	XP_036020624.1	Gene:	Ache / 11423	MGIID:	87876	Length:	616	Species:	Mus musculus

Alignment Length:	604	Identity:	199/604 - (32%)
Similarity:	289/604 - (47%)	Gaps:	123/604 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MLFVVELLVLLASSSVLSIEVDTE-LGRVRGANLTS-RL---GVNFHAFRGIRYAEPPLGDLRFV 62
            :||:  ||.||...:......|.: |.||||..|.. ||   |....||.||.:||||:|..||:
Mouse    17 LLFL--LLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFM 79

  Fly    63 NPQPVKPWSPKIFDASEDGPMCPQ-------------PWDNMTDVSEDCLRLNVYTKDLK--GRR 112
            .|:|.:||| .:.||:....:|.|             .|:...::|||||.|||:|...:  ...
Mouse    80 PPEPKRPWS-GVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPT 143

  Fly   113 PVIVFLHPGGFY-------VFSGQSKYLAGPEHFMDRDCVLVSLNYRLGSLGFLA-TGSKEAPGN 169
            ||:::::.||||       |:.|  ::||..|     ..||||:|||:|:.|||| .||:|||||
Mouse   144 PVLIWIYGGGFYSGAASLDVYDG--RFLAQVE-----GAVLVSMNYRVGTFGFLALPGSREAPGN 201

  Fly   170 AGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGP 234
            .||.||.|||:|:|::|..|||||.||||.|.|||:.||.:|:||..||.||||.:..|..|.||
Mouse   202 VGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGP 266

  Fly   235 VKYKDNDLQLAKRQAGLLK----CPQESIG----EMVECMRRKPYLD------YVSTYNGMFEFG 285
              :.......|:|:|.||.    ||....|    |::.|:|.:|..|      :|.....:|.|.
Mouse   267 --WATVSAGEARRRATLLARLVGCPPGGAGGNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFS 329

  Fly   286 WNPVLNWRIVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFEFLSGAF--------FDLR 342
            :.|      ||:.||     |.::|......|||..:.::.|:.:.|   |::        |...
Mouse   330 FVP------VVDGDF-----LSDTPEALINTGDFQDLQVLVGVVKDE---GSYFLVYGVPGFSKD 380

  Fly   343 NESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKL--EYPKSLK-GMGELLS 404
            |||:::|.    :..|.:.:.:.|       ||.:..|..:....|.|  |.|..|: .|..::.
Mouse   381 NESLISRA----QFLAGVRIGVPQ-------ASDLAAEAVVLHYTDWLHPEDPTHLRDAMSAVVG 434

  Fly   405 D--------ALIGVSFHRFLQLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFH 461
            |        .|.|       :|.:....:|.|:|.:  |.:.|..|   ..:|..|..|:.::|
Mouse   435 DHNVVCPVAQLAG-------RLAAQGARVYAYIFEH--RASTLTWP---LWMGVPHGYEIEFIF- 486

  Fly   462 VGL-LIPLLKREDPENFMIELLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGY------- 518
             || |.|.|.....|....:.|.:.|..||:.|||::..|.  |...||.|....:.|
Mouse   487 -GLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDS--KSPQWPPYTTAAQQYVSLNLKP 548

  Fly   519 LEIGNNLTAKSGGFFLNRY 537
            ||:...|.|::..|: ||:
Mouse   549 LEVRRGLRAQTCAFW-NRF 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	193/592 (33%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	82/186 (44%)
Ache	XP_036020624.1	COesterase	37..563	CDD:395084	189/576 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832848
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840