DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4757 and Ces1d

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_579829.3	Gene:	Ces1d / 113902	RGDID:	70896	Length:	565	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	173/568 - (30%)
Similarity:	250/568 - (44%)	Gaps:	123/568 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VDTELGRVRGANLTSRLGVNFHAFR-------GIRYAEPPLGDLRFVNPQPVKPWSPKIFDASED 80
            |:|..|:|.|..      ||...|.       ||.:|:||||.|||..|||.:||: .:.:.:..
  Rat    26 VNTVKGKVLGKY------VNLEGFAQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWN-FVKNTTSY 83

  Fly    81 GPMCPQP----------WDNMTD-----VSEDCLRLNVYT-KDL--KGRRPVIVFLHPGGFYVFS 127
            .|||.|.          :.|..:     .|||||.||||| .||  ..|.||:|::|.||. |..
  Rat    84 PPMCSQDAVGGQVLSELFTNRKENIPLQFSEDCLYLNVYTPADLTKNSRLPVMVWIHGGGL-VVG 147

  Fly   128 GQSKY----LAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQR 188
            |.|.|    |:..|     :.|:|::.||||..||.:||.:.:.||.|..|||.||.|:|.:|..
  Rat   148 GASTYDGQVLSAHE-----NVVVVTIQYRLGIWGFFSTGDEHSQGNWGHLDQVAALHWVQDNIAN 207

  Fly   189 FGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAKRQAGLLK 253
            |||:|.|||:.|.|||..||:..:|||:::.||||.|..|...........:...:|...|.|..
  Rat   208 FGGNPGSVTIFGESAGGFSVSALVLSPLAKNLFHRAISESGVVLTSALITTDSKPIANLIATLSG 272

  Fly   254 CPQESIGEMVECMRRKPYLDYVSTY------------NGMFEFGWNPVLNWRIVVEKDFGQERYL 306
            |...:...||.|:|:|...:.:.|.            |....:.:.|.:...:|:.|.  .|..|
  Rat   273 CKTTTSAVMVHCLRQKTEDELLETSLKLNLFKLDLLGNPKESYPFLPTVIDGVVLPKT--PEEIL 335

  Fly   307 IESPFKTARRGDFHKVALITGITEFEF-----------LSGAFFDLRN-ESIVNRYNRDWEHYAS 359
            .|..|.|        |..|.||.:.||           ||....|.:. :|::      |:.|.:
  Rat   336 TEKSFNT--------VPYIVGINKQEFGWIIPTLMGYPLSEGKLDQKTAKSLL------WKSYPT 386

  Fly   360 IALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGM-GELLSDALIGV------SFHRFLQ 417
            :.:        |.....|..|||...:.|    |...|.: .:|::|.:.||      ..||
  Rat   387 LKI--------SEKMIPVVAEKYFGGTDD----PAKRKDLFQDLVADVMFGVPSVMVSRSHR--- 436

  Fly   418 LMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLK--REDPENFMIE 480
              ....|.:.|.|.|:..:.....|   :|:...|.|||..:|.    .|.||  ..:.|..:.:
  Rat   437 --DAGAPTFMYEFEYRPSFVSAMRP---KTVIGDHGDELFSVFG----SPFLKDGASEEETNLSK 492

  Fly   481 LLTRMWIEFAQKGDPHNKNDEYLKGL-NWPLYNAQDKGYLEIGNNLTA 527
            ::.:.|..||:.|.|:.      .|| :||.|: |.:|||:||.:..|
  Rat   493 MVMKYWANFARNGSPNG------GGLPHWPEYD-QKEGYLKIGASTQA 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	173/568 (30%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	78/192 (41%)
Ces1d	NP_579829.3	COesterase	24..545	CDD:278561	173/568 (30%)
		Aes	<121..>239	CDD:223730	55/123 (45%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336150
Domainoid	1	1.000	232	1.000	Domainoid score	I2325
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.000