Protein Alignment CG4757 and CES1

DIOPT Version :10

• Sequence 1: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001020366.1
• Gene: CES1 / 1066
• HGNCID: 1863
• Length: 568
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 184/583 - (31%)
• Similarity: 271/583 - (46%)
• Gaps: 118/583 - (20%)

  Fly    23 VDTELGRVRGANLT-SRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMCPQ 86
            |||..|:|.|..:: .........|.||.:|:||||.|||..|||.:||| .:.:|:...|||.|
Human    27 VDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWS-FVKNATSYPPMCTQ 90

  Fly    87 P----------WDNMTD-----VSEDCLRLNVYT-KDL--KGRRPVIVFLHPGGFYVFSGQSKY- 132
            .          :.|..:     :|||||.||:|| .||  |.|.||:|::|.||..| ...|.|
Human    91 DPKAGQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMV-GAASTYD 154

  Fly   133 -LAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSV 196
             ||...|   .:.|:|::.||||..||.:||.:.:.||.|..|||.||||:|.:|..|||:|.||
Human   155 GLALAAH---ENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSV 216

  Fly   197 TLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQ-LAKRQAGLLKCPQESIG 260
            |:.|.|||..||::.:|||:::.||||.|..|......|..|..|:: ||::.|....|...:..
Human   217 TIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSA 281

  Fly   261 EMVECMRRKPYLDYVSTYNGMFEFGWN---------PVLNWRIVVEKDFGQERYLIESPFKTARR 316
            .||.|:|:|...:.:.|...|.....:         |:|...|       ....|:::|.:....
Human   282 VMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVI-------DGMLLLKTPEELQAE 339

  Fly   317 GDFHKVALITGITEFEF------------LSGAFFDLRNE-SIVNRYNRDWEHYASIALLLE--Q 366
            .:||.|..:.||.:.||            ||....|.:.. |::      |:.|..:.:..|  .
Human   340 RNFHTVPYMVGINKQEFGWLIPMQLMSYPLSEGQLDQKTAMSLL------WKSYPLVCIAKELIP 398

  Fly   367 NSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGVSF------HRFLQLMSPHTPI 425
            .:|          |||:..:.|.:: .|.|  ..:|::|.:.||..      ||     ....|.
Human   399 EAT----------EKYLGGTDDTVK-KKDL--FLDLIADVMFGVPSVIVARNHR-----DAGAPT 445

  Fly   426 YTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKR--EDPENFMIELLTRMWIE 488
            |.|.|:|:..::....|   :|:...|.|||..:|..    |.||.  .:.|..:.:::.:.|..
Human   446 YMYEFQYRPSFSSDMKP---KTVIGDHGDELFSVFGA----PFLKEGASEEEIRLSKMVMKFWAN 503

  Fly   489 FAQKGDPHNKNDEYLKGL-NWPLYNAQDKGYLEIGNNLTA------KSGGFFLNRYQIWEDLF 544
            ||:.|:|:.      :|| :||.|| |.:|||:||.|..|      |...|       |.:||
Human   504 FARNGNPNG------EGLPHWPEYN-QKEGYLQIGANTQAAQKLKDKEVAF-------WTNLF 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	181/577 (31%)
CES1	NP_001020366.1	COesterase	23..548	CDD:395084	181/577 (31%)