Protein Alignment CG4757 and CEL

DIOPT Version :9

• Sequence 1: NP_001262469.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001798.3
• Gene: CEL / 1056
• HGNCID: 1848
• Length: 753
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 160/585 - (27%)
• Similarity: 244/585 - (41%)
• Gaps: 106/585 - (18%)

  Fly     2 LMLFVVELLVLLASSSVLSI-EVDTELGRVRGAN-LTSRLGVNFHAFRGIRYAEPPLGDLRFVNP 64
            |.|.|:.|....|.:|...: .|.||.|.|.|.| ....||.:...|:||.:|.|...   ..||
Human     4 LQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKA---LENP 65

  Fly    65 QPVKPWSPKIFDASEDGPMCPQP--WDNMTDVSEDCLRLNVYTKDLKGRR------PVIVFLHPG 121
            ||...|...: .|......|.|.  ..:.|...||||.||::..  :||:      ||:::::.|
Human    66 QPHPGWQGTL-KAKNFKKRCLQATITQDSTYGDEDCLYLNIWVP--QGRKQVSRDLPVMIWIYGG 127

  Fly   122 GFYVFSGQ-----SKYLAGPEHFMDR-DCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALR 180
            .|.:.||.     :.||...|....| :.::|:.|||:|.||||:||....|||.||:||.:|:.
Human   128 AFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIA 192

  Fly   181 WIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLA 245
            |::::|..|||||:::||.|.|||..||:|..|||.::||..|.|..|.....|...:.|.|..|
Human   193 WVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWA 257

  Fly   246 KRQAGLLKCPQESIGEMVECMR------------------RKPYLDYVSTYNGMFEFGWNPVLNW 292
            |:.|..:.||......|.:|::                  ..|.|.||         |:.||::
Human   258 KKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHYV---------GFVPVID- 312

  Fly   293 RIVVEKDFGQERYLIESPFKTARRGDF---HKVALITGITEFEFLSGA------FFDLRNESIVN 348
                                    |||   ..:.|.....:.::::|.      .|...:...:|
Human   313 ------------------------GDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAIN 353

  Fly   349 RYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDAL------ 407
            :.|:.........|:.|...|:....::...:.|..............|.:.:..:|.|
Human   354 KGNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTE 418

  Fly   408 IGVSFHRFLQLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKRE 472
            |.::.|| ....|..|  |.|||.:..|.     |...:.:|..|.|::.|:|......|...|
Human   419 IALAQHR-ANAKSAKT--YAYLFSHPSRM-----PVYPKWVGADHADDIQYVFGKPFATPTGYR- 474

  Fly   473 DPENFMI-ELLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSGGFFLNR 536
             |::..: :.:...|..||:.||| |..|..:. .:|..|..::.|||||    |.|.|...:.|
Human   475 -PQDRTVSKAMIAYWTNFAKTGDP-NMGDSAVP-THWEPYTTENSGYLEI----TKKMGSSSMKR 532

  Fly   537  536
            Human   533  532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	155/572 (27%)
		Aes	40..>204	CDD:223730	63/177 (36%)
CEL	NP_001798.3	Heparin-binding	21..121		32/105 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..753
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142714
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740