DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4757 and ces3.5

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	XP_031756661.1	Gene:	ces3.5 / 100493652	XenbaseID:	XB-GENE-6467133	Length:	557	Species:	Xenopus tropicalis

Alignment Length:	592	Identity:	185/592 - (31%)
Similarity:	273/592 - (46%)	Gaps:	106/592 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LMLFVVELLVLLASSSVLSIEVDTELGRVRGANLTSRLGV--NFHAFRGIRYAEPPLGDLRFVNP 64
            |:|..|.|.:..|........:.|:.|::.|..:..| |.  :.|||.|:.:|:.|:|.|||.:|
Frog     8 LLLCCVTLEIYGAGQEDARPRLTTKYGQLLGKTVNVR-GADRHVHAFMGVPFAKAPVGHLRFADP 71

  Fly    65 QPVKPWSPKIFDASEDGPMCPQPWDNMTDV-------------SEDCLRLNVYT-KDLK--GRRP 113
            ||.:||| .|.:||...|||.|  ..|..:             |||||.|||:| .|.|  .:.|
Frog    72 QPPEPWS-SIREASVIPPMCLQ--HGMEQLIKLFKIEFVLPASSEDCLYLNVFTPADRKENSKLP 133

  Fly   114 VIVFLHPGGFY-----VFSGQSKYLAGPEHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLK 173
            |:||:|.||..     :|.|.:  |:|.|     :.|:||:.||||.|||.:||.|||.||.|..
Frog   134 VMVFIHGGGLLMGLASMFDGSA--LSGYE-----NVVVVSIQYRLGILGFFSTGDKEAQGNFGFL 191

  Fly   174 DQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGP---V 235
            |||.||:|:|::|:.|||||:|||:.|.|||.:||:.|:|||:|:|||||.|..|.....|   |
Frog   192 DQVAALKWVQENIKEFGGDPESVTIFGQSAGGLSVSTHVLSPLSKGLFHRAIAESGVALLPGLVV 256

  Fly   236 KYKDNDLQLAKRQAGLLKCPQESIGEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIVVEKDF 300
            ...:..|.:....|.|..|   :|..:|:|:::|.. :.:...:...:|...|.....:.:.|..
Frog   257 SKTEEVLFVRDLVASLSGC---NIKGLVDCLKKKTE-EEIMAISATMQFTALPACVDGVFLPKPV 317

  Fly   301 GQERYLIESPFKTARRGDFHKVALITGITEFEF---------LSGAFFDLRNESIVNRYNRDWEH 356
              |..|...        :.::|..:.|....||         :||.           |.....:.
Frog   318 --EEILANK--------ESNRVPFLIGFNNNEFGWMLPMALNISGF-----------REGMGRKE 361

  Fly   357 YASIALLLEQNSTQSRAASRVFREKYMPESLDKLEY-PKSLKGMGELL--SDALIGVSFHRFLQL 418
            ..|:...|....:.|.....:.:| |..::.|:.|. .|.|:..|::|  ..||....:||...|
Frog   362 VQSVLSALPLLHSVSSLVPLLMKE-YFGDTNDQTEIRNKFLELNGDILFVIPALRTAQYHRDSGL 425

  Fly   419 MSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKRE--------DPE 475
                 |:|.|.|:::   ..|.:......:...|.|||.::    |..|.|..:        |.|
Frog   426 -----PVYLYEFQHR---PSLYDNSKDDFVKADHGDELYFV----LGGPFLNGDAIFQSDGTDEE 478

  Fly   476 NFMIELLTRMWIEFAQKGDPHNKNDEYLKGL-NWPLYNAQDKGYLEIGNNLTAKSGGFFL-NRYQ 538
            ..:.:.:.:.|..||:.|||:.      .|| .||.|: :||.||||  ||..||..... .|.:
Frog   479 KNLSKTMMKYWANFARNGDPNG------PGLVEWPAYD-EDKDYLEI--NLKQKSSWRLKEGRLK 534

  Fly   539 IWEDLFP 545
            .|....|
Frog   535 FWTVTLP 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	178/572 (31%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	84/186 (45%)
ces3.5	XP_031756661.1	COesterase	27..536	CDD:395084	178/566 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010